Immunology CD4+ T cell mediated tumor immunity following transplantation of TRP-1 TCR gene modified hematopoietic stem cells INDIANA UNIVERSITY Christopher E. Touloukian HaSung PilImmunotherapy for cancer has held much promise as a potent modality of cancer treatment. The ability to selectively destroy...
. The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4(+) T cells . Nat. Immunol. 15 , 1055–1063 (2014).Bertin S, Aoki-Nonaka Y, de Jong PR, Nohara LL, Xu H, Stanwood SR, Srikanth S, Lee J, To K, Abramson L, Yu T, Han T, Touma R, Li X...
Furthermore, TRPV1 activation is also involved in regulating immune cell activity, including the activation of CD4-positive T cells and the proinflammatory phenotype polarization of macrophages (M1)16,17. In contrast, a recent study has shown that TRPV1 modulates M1/M2 macrophage polarization and...
Asthma prevalence has increased world-wide especially in children; thus there is a need to develop new therapies that are safe and effective especially for patients with severe/refractory asthma. CD4+ T cells are thought to play a central role in disease
The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4(+) T cells. Nat Immunol. 2014;15(11):1055–63. Article CAS PubMed PubMed Central Google Scholar Lozano C, Cordova C, Marchant I, Zuniga R, Ochova P, Ramirez-Barrantes R, et al. Intracellular ...
T cells by controlling the T cell receptor signaling complex44. The activation of TRPV1 also stimulates extracellular-signal-regulated, c-Jun N-terminal, and p38 mitogen-activated protein kinases and releases the cytokines IL-6 and -8 in a manner that is dependent on extracellular Ca2+levels ...
Later, TRPV1 expression was reported in non-neuronal system cells, such as arteriolar smooth muscle cells [13, 14] and the bladder urothelium [15]. TRPV1 is a nonselective cation channel that can be activated by different physical and chemical stimuli, including temperatures over 43°C, ...
(Billeter et al.,2015). The activation of TRPA1 by cinnamaldehyde acts on adaptive immunity by suppressing lymphoproliferation and promoting T-cell maturation, as revealed by T-cell differentiation from CD4 and CD8 double-positive cells to CD4 or CD8 single-positive cells in LPS-treated mouse ...
CD4+T cells are regarded as pivotal in inflammation, resulting in the infiltration of eosinophils and the activation of mast cells, followed by tissue remodeling, excessive airway mucus secretion, and airway hyperresponsiveness3. Though it is well known that immune mechanisms play a critical part in...
An early sympathetic nervous system influence exacerbates collagen-induced arthritis via CD4 + CD25+ cells. Arthritis Rheum. 2008;58:2347–55. Article PubMed Google Scholar Bartok B, Firestein GS. Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis. Immunol Rev. 2010;233:...