We demonstrated the functional expression of TRPA1 on the plasma membrane of CD4+ T cells and identified that Trpa1(-/-) CD4+ T cells have increased T-cell receptor-induced Ca(2+) influx, activation profile and differentiation into Th1-effector cells. This phenotype was abrogated upon genetic...
While TRPV1 contributes to T cell receptor (TCR)-induced Ca2+ influx and CD4+ T cell activation, TRPA1 negatively regulates those events. Therefore, TRPV1 and TRPA1 in CD4+ T cells appear to play pro- and anti-inflammatory roles, respectively. Finally, we found differential regulation of ...
nanomaterialsArticleInhibitionofTRPV1ChannelActivityinHumanCD4+TCellsbyNanodiamondandNanoplatinumLiquid,DPV576MamdoohH.Ghoneum1,*,JamesK.Gimzewski2,3,AyaGhoneum2,HidekiKatano4,ClarissaNilaPawU5andAnshuAgrawal51DepartmentofSurgery,CharlesDrewUniversityofMedicineandScience,LosAngeles,CA90059,USA2DepartmentofChemis...
Supplementary Figure 4: Trpv1–/– and WT CD4+ T cells display similar apoptosis and proliferative response. | Nature Immunology Supplementary Figure 4: Trpv1–/– and WT CD4+ T cells display similar apoptosis and proliferative response. From: The ion channel TRPV1 regulates the activation ...
Immunology CD4+ T cell mediated tumor immunity following transplantation of TRP-1 TCR gene modified hematopoietic stem cells INDIANA UNIVERSITY Christopher E. Touloukian HaSung PilImmunotherapy for cancer has held much promise as a potent modality of cancer treatment. The ability to selectively destroy...
Trp-P-1, a carcinogenic heterocyclic amine, inhibits lipopolysaccharide-induced maturation and activation of human dendritic cells Author links open overlay panelJun Ho Jeon b 1, Sun Kyung Kim a 1, Jintaek Im a, Ki Bum Ahn a, Jung Eun Baik a, ...
activation and acquisition of the inflammatory properties of T cells by controlling the T cell receptor signaling complex44. The activation of TRPV1 also stimulates extracellular-signal-regulated, c-Jun N-terminal, and p38 mitogen-activated protein kinases and releases the cytokines IL-6 and -8 ...
The role of TRPV1 in the CD4+ T cell-mediated inflammatory response of allergic rhinitis Transient receptor potential vanilloid 1 (TRPV1), which has been identified as a molecular target for the activation of sensory neurons by various painful ... S Ramachandran,KD Woo,SH Ran,... - 《Onc...
Conclusion: We conclude that short term exposure to DPV576 inhibits the activity of TRPV1 channels in CD4+ T lymphocytes, which may suggest its possible beneficial use for pain management. Keywords: nanodiamond; CD4+ T cells; TRPV1; capsaicin 1. Introduction Tissue damage, due to noxious ...
CD4(+)CD25(+) regulatory T cells (Tregs) represent a unique T-cell lineage that is endowed with the ability to actively suppress immune responses in order to inhibit pathogenic damage resulting from over activation of the immune system. In human immunodeficiency virus-1 (HIV-1) infection, supp...