作者基于TCGA和GEO数据库,系统性地分析了与CD4+conventional Tcells相关的lncRNAs在肝细胞癌中的预后价值,并探索了与免疫微环境之间的关系。对于该思路有兴趣的老师可以与我们联系,方法适用于其他疾病。 背景: 肝细胞癌(hepatocellularcarcinoma,HCC)是癌症相关死亡的第二大原因,在世界范围内的发病率不断上升。HCC主要...
我们分析并可视化了肝癌的主要细胞类型,其中传统的CD4+ T细胞占HCC免疫微环境的很大比例。 2.CD4+tconv相关基因和lncRNAs的鉴定和功能富集 我们在两个平台上从GSE140228中获得了CD4+Tconv相关基因,并确定了478个交叉的CD4+Tconv相关基因。在交叉的CD4+Tconv相关基因的基础上,通过GO和KEGG通路富集分析,明确了这些基...
We find that CD4+ T cells regulate the number and function of barrier-protective innate lymphoid cells (ILCs), as well as production of antimicrobial peptides (AMPs), Reg3纬 and Reg3尾. RAG1-/- mice lacking T and B cells had elevated ILC numbers, interleukin-22 (IL-22) production, ...
Regulatory CD4+T cells (Treg) prevent tumor clearance by conventional T cells (Tconv) comprising a major obstacle of cancer immune-surveillance. Hitherto, the mechanisms of Treg repertoire formation in human cancers remain largely unclear. Here, we analyze Treg clonal origin in breast cancer patient...
Improvements to the first CD4-based CAR include strategies to improve T cell persistence, broaden target specificity, and resist infection of the engineered T cells [51], [52]. Ligand-based CARs have also been developed as anti-cancer therapies. Kahlon et. al. first described “IL-13-zeta...
The CD4+CD25- Tcell reactivity depends on MHC classII presentation, specific TCR stimulation, CD4 ligation, and antigen processing by antigen-presenting cells. The CD4+CD25- Tcells respond to autologousand heterologous enterobacterial antigens, but not to antigens from the feces of germ-free ...
CD4+Foxp3− T Cells Expressing PD-1 (4PD1hi) Accumulate at the Tumor Site in Mice and Humans To begin investigating the role of 4PD1hi, we assessed 4PD1hi tissue distribution in untreated naive and B16 melanoma-bearing mice and observed that these cells are significantly enriched at the ...
Non-conventional Inhibitory CD4(+)Foxp3(-)PD-1(hi) T Cells as a Biomarker of Immune Checkpoint Blockade Activity (vol 33, pg 1017, 2018) Non-conventional inhibitory CD4(+)Foxp3(-)PD-1(hi) T cells as a biomarker of immune checkpoint blockade activity. Cancer Cell (2018) 33:1017-32 ...
Another particular effect that is elicited by LSECs during their interaction with CD4+ T cells, is the imprinting of a gut tropism phenotype, that is, CD4+ T cells acquire integrin α4β7 and CC-chemokine receptor 9 (CCR9) expression.36 This LSEC-induced expression of gut homing molecules...
Conventional and Unconventional T Cells 来自 Springer 喜欢 0 阅读量: 80 作者:S Roberts,M Girardi 摘要: T lymphocytes that express an αβ T cell receptor (TCR), as well as a co-receptor CD4 or CD8, are present in the peripheral blood, lymph nodes, and tissues (such as the skin), ...