Definition TrkA is a member of the trk family of tyrosine kinase receptors and is the high affinity receptor for nerve growth factor found on NGF-dependent sensory neurons. When trkA binds NGF, the receptor autophosphorylates on tyrosine residues, leading to activation of multiple downstream ...
trkA cannot act alone to influence cellular function—the proper complement of intracellular signaling systems must be present. As the understanding of general transmembrane receptor signaling has increased, so too has that specifically of NGF:trkA signaling. There has been a significant increase in the...
growth and differentiation of nerve cells. It is distributed throughout the body and plays different pathophysiological roles according to the combined receptors. TrkA is its high affinity receptor, and many studies have shown ...
2) TRKA receptor TRKA受体 1. Objective To explore the underlying mechanisms of morphine tolerance in spinal cord by studying the effect of low dose morphine continually administered intraperitoneally after chronic stricture injury (CCI) on the hyperalgesia and the expression of c-fos and TrkA ...
英文名称: Human tyrosine kinase receptor (TrkA)ELISA kit 用途: 科研试验 产地: 上海 品牌: 佰利莱生物 包装规格: 96T/48T 标记物: HRP标记物 样本: 血清,血浆,唾液,尿液,组织,细胞上清,裂解液等 检测方法: 酶联免疫法 应用: 定性检测/定量检测/酶活检测 检测限: 0- 货号: BLL108767E ...
TrkB (white) was engineered so that the D5 domain was replaced by the same domain of the TrkA (black) receptor. The resulting chimera is termed 4.1. B, model of TrkA-ECD and TRKA-D4–D5 proteins with indicated binding or possible allosteric sites for NGF, NT-3, mAb 5C3, and NGF-...
However, NT-3 docking solely on site 1 is partially agonistic but noncompetitively antagonizes NGF binding and activation of Trk. This study demonstrates that Trk signaling is more complex than previously thought because it involves several receptor subdomains and hot spots. 展开 ...
TrkA在各种神经元和非神经元细胞类型的细胞存活、分化和凋亡中起重要作用。GW441756可以以剂量依赖的方式特异性阻断TrkA诱导的细胞死亡。 产品信息 英文别名 (English Synonym) GW441756, GW-441756 靶点 (Target) TrkA 通路 (Pathway) Neuronal Signaling--Trk Receptor CAS号 (CAS NO.) 504433-23-2 分子...
3) TRKA receptor TRKA受体 1. Objective To explore the underlying mechanisms of morphine tolerance in spinal cord by studying the effect of low dose morphine continually administered intraperitoneally after chronic stricture injury (CCI) on the hyperalgesia and the expression of c-fos and TrkA ...
NGF was the first neurotrophin to be discovered, more than 50 years ago. Three other proteins have been added to the list: BDNF, NT-3 and NT-4 (NT-4/5). These neurotrophins bind two groups of receptors. The p75NTR receptor is common to all four neurotrop