英文名称:Trk Receptors品牌厂商性质产地货期 MedChemExpress (MCE) 生产商 美国 现货性能特点 Trk 家族由 TrkA、TrkB 和 TrkC 三种受体酪氨酸激酶 (RTKs) 组成,又称为神经营养酪氨酸受体激酶(NTRK1-NTRK3),作为神经生长因子 (NGF)、脑源性神经营养因 ...
TRK融合蛋白将持续激活,触发一个永久性的信号级联,驱动TRK融合肿瘤的增殖和生长。 Figure 3. Schematic representation of TRK receptors signaling pathways. 3. NTRK基因异常与肿瘤 3.1 NTRK突变、剪接变异体和TRK过度表达 现已证实,TRK是通过NTRK融合、突变、剪接变异体和TRK过...
The -related tyrosine kinase () receptors were initially described as a family of growth factor receptors required for neuronal survival. They have since been shown to influence many aspects of neuronal and function, including differentiation, outgrowth, and synaptic plasticity. This chapter will give...
Larotrectinib (LOXO-101) is an orally administered inhibitor of the TRK kinase and is highly selective only for the TRK family of receptors(IC50s = 2-20 nM). 靶点活性 Trk:2-20 nM 体内活性 在体内,Larotrectinib(60 mg/kg 和 200 mg/kg)通过减少KM12小鼠异种移植模型中的肿瘤生长来发挥作用...
Trk receptorshave intrinsic kinase activity, and dimerize upon the binding of the dimeric neurotrophin ligand. Three Trk receptors have been identified: TrkA, B and C. TrkA specifically interacts with NGF, while TrkB binds to both BDNF and NT-4. TrkC is the specific receptor for NT-3 (Figure...
关键词: TLQP 21, TLQP 21 supplier, VGF-derived, peptide, Neurotrophin, Receptors, TLQP21, Other, Apoptosis, Trk, 3051, Tocris Bioscience Submit a Review & Earn an Amazon Gift Card You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide ...
The Trk receptors are expressed in neuronal tissues, and guide the development of the central and peripheral nervous systems during development. We quantify the dimerization of human Trk-A, Trk-B, and Trk-C in the absence and presence of their cognate ligands: human β-nerve growth factor, ...
Ligand-dependent activation of the prototype TRK tyrosine kinase receptor sends intracellular signals into nucleus and induces growth arrest, differentiation and promotion of survival in neuronal cells. Inneuroblastomaandmedulloblastoma, expression levels of the prototype TRK receptors modulate tumor cell biolo...
We show that catalytically active Trk receptors are located within the axon of adult rat sciatic nerve and that they are distributed throughout the length of the axons. These catalytically active receptors are phosphorylated on tyrosine at a position that couples them to the signal-generating ...
With the aim to examine the distribution of high-affinity neurotrophin receptors (tyrosine kinase receptors, TrkA, TrkB and TrkC) in the rat Scapa's ganglion (vestibular ganglion, VG), Avidin-Biotin-peroxidase Complex (ABC) method of immunohistochemistry with diaminobenzidine (DAB) as the chromogen...