Cell Signaling Transduction Growth Factor Signaling Transduction RTK Receptor Tyrosine Kinase (RTK) Background Receptor tyrosine kinases (RTKs)are essential components of signaling transduction that mediate cell-to-cell communication. The RTK family includes, epidermal growth factor receptor (EGFR), platelet...
Most of the DEGs were significantly enriched in immune system process, cell communication, immune system and signaling by NTRK1 (TRKA). Through PPI, modules, miRNA-hub gene regulatory network, TF-hub gene regulatory network analysis, ESR1, UBD, FYN, STAT1, ISG15, EGR1, ARRB2, UBE2D1, ...
showpreviewIL6ST,LIF,MAP2K5,MAP3K8,MAPK7,MEF2,MEKK2/3,MYC,NGF,NGF-TRKA,NTRK1,PTPN11,Ras,Rsk,SGK1,SH2D2A,SRC,transcription, WNK1 DrugSummary-OverviewofdrugstargetingmoleculesinCanonicalPathway Showing3of95row(s)ofDrugdata. DrugNameTargetsActionsBranmesIndications/Status ...
Members of the tropomyosin-related kinase (Trk) family are tyrosine kinase receptors: TrkA (NTRK1), TrkB (NTRK2), and TrkC (NTRK3). Primary ligands with high affinity are nerve growth factor (NGF) for TrkA, brain- derived neurotrophic factor (BDNF) for TrkB, and neurotrophin-3 (NT-3)...
Abstract Neurotrophins (NTs) are members of a neuronal growth factor protein family whose action is mediated by the tropomyosin receptor kinase (TRK) receptor family receptors and the p75 NT receptor (p75NTR), a member of the tumor necrosis factor (TNF) receptor family. Although NTs were first...
By contrast, NGF causes ERK phosphorylation that persists for up to 30 min, which is shown by the significant difference a Kidins220 Actin b 0.0 5.3556747 6.823868 BDNF NTRK2 NTRK2 NGFR MYCN NTRK2 DCX GAPDHS MYCN GAPDH NTRK2 NTRK1 NTRK2 ALK KIDINS220 BDNF ALK NGFB NGFB Figure 1. ...
Congenital insensitivity to pain with anhidrosis (CIPA; MIM 256800) is an autosomal-recessive disorder characterized by recurrent episodes of unexplained f... Y Indo,M Tsuruta,Y Hayashida,... - 《Nature Genetics》 被引量: 1140发表: 1996年 Mutation and polymorphism analysis of the TRKA (NTRK1)...
Deconvolution of the collective framework into discrete sub-networks identified a module with the highest score that enriched for Cardiovascular System Development, and revealed NTRK1/TRKA and SRSF2/SC35 as critical hubs within this cardiogenic module. The strategy of pluripotent transcriptome ...
Recently, we identified a family co-segregat- ing for bipolar disorder and medullary cystic kidney disorder where linkage studies implicated the 1q region containing the gene for NTRK1, which codes for TrkA, the receptor for NGF. Methods: We have explored the role of NTRK1 in bipolar ...
We report that supernatants of dying cancer cells induced substantial IL-10 release from primary human M桅s, dependent on signaling through tyrosine kinase receptor A (TRKA or neurotrophic tyrosine kinase receptor type 1 (NTRK1)). Mechanistically, sphingosine-1-phosphate (S1P) release from apoptotic...