[89] and the endogenous ligand podoplanin, a protein expressed on lymphatic but not vascular endothelium [90]. Human CLEC-2 has one YXXL motif in its cytoplasmic tail which undergoes tyrosine phosphorylation by Src kinases upon ligand binding [89]. Binding of podoplanin by CLEC-2 expressed on...
The results demonstrated that inhibition of PI3K completely abrogates GLP-1-induced phosphorylation of PKB and ERK1/2, suggesting that activation of PI3K was upstream to both kinases. On the other hand, the inhibition of MEK1/2 did not affect PKB, but only ERK1/2 (as expected), indicating...