Triple-negative breast cancer (TNBC) is a subtype of breast cancer known for its high aggressiveness and poor prognosis. Conventional treatment of TNBC is challenging due to its heterogeneity and lack of clear targets. Recent advancements in immunotherapy have shown promise in treating TNBC, with im...
These findings could open new doors for treating patients with triple-negative breast cancer, say the study's corresponding authors Xia Liu, Ph.D., and Jinming Yang, M.D., Ph.D., both faculty members in the UK College of Medicine's Department of Toxicology and Cancer Biology. "This study...
Synonyms Estrogen receptor, progesterone receptor, and HER-2 negative ; TNBC Definition Triple-negative breast cancer (TNBC) is a subgroup that accounts for 10鈥 20 % of all breast carcinomas. TNBC is characterized by the absence of three receptors: estrogen receptor (ER), progesterone receptor ...
Triple negative breast cancer (TNBC), which accounts for 15–20% of incident breast cancers, is the only breast cancer (BC) subtype that lacks targeted treatments. Using clinical assays, TNBC is human epidermal growth factor receptor 2 (HER2) negative and has <1% expression of estrogen receptor...
Triple-negative breast cancer (TNBC), a highly aggressive subtype of breast cancer, negatively expresses estrogen receptor, progesterone receptor, and the human epidermal growth factor receptor 2 (HER2). Although chemotherapy is the main form of treatment for patients with TNBC, the effectiveness of ...
What set the alarm bells ringing is that Kashmir has the second highest prevalence of triple-negative breast cancer, which is around 33 to 35%
Triple negative breast cancer is more often responsive to chemotherapy than hormone receptor positive (ER+/PR+) breast cancer. On the other hand, long-term hormonal treatments (tamoxifen, aromatase inhibitors) used for ER+ subtypes are not effective for triple negative breast cancer since estrogen ...
Triple-Negative Breast Cancer Some breast cancers -- between 10% and 20% -- are known as “triple negative” because they don’t have estrogen and progesterone receptors and don’t overexpress the HER2 protein. Many breast cancers associated with the gene BRCA1 are triple negative. They are ...
Depletion of mitochondrial copper, which shifts metabolism from respiration to glycolysis and reduces energy production, is known to be effective against cancer types that depend on oxidative phosphorylation. However, existing copper chelators are too to
Hemin sensitizes triple-negative breast cancer to metformin by degrading BACH1, a University of Chicago-led team has found. (nito100/iStock/Getty Images Plus) 而近日由芝加哥大学科学家团队通过细胞系和小鼠肿瘤模型的研究表明,将2种治疗糖尿病和卟啉症的药物-二甲双胍&血红素 -进行组合,可以抑制三阴性乳...