三阴性乳腺癌是一种最具侵袭性的乳腺癌亚型,这类患者主要采用新辅助化疗(NAC,neoadjuvant chemotherapy)手段进行治疗。近日,一篇发表在国际杂志Breast Cancer Research上题为“Integration of multiomics data shows down regulation of mismatch repair and tubulin pathways in triple-negative chemotherapy-resistant breast ...
Triple-Negative Breast Cancer Some breast cancers -- between 10% and 20% -- are known as “triple negative” because they don’t have estrogen and progesterone receptors and don’t overexpress the HER2 protein. Many breast cancers associated with the gene BRCA1 are triple negative. They are ...
Triple negative breast cancer is more often responsive to chemotherapy than hormone receptor positive (ER+/PR+) breast cancer. On the other hand, long-term hormonal treatments (tamoxifen, aromatase inhibitors) used for ER+ subtypes are not effective for triple negative breast cancer since estrogen ...
关键词:群体基因组;三阴性乳腺癌(TNBC);淋巴结转移(LNM); 文献介绍 标题(英文):Prediction of axillary lymph node metastasis in triple-negative breast cancer by multi-omics analysis and an integrated model 标题(中文):基于多组学分析和整合模型的三阴性乳腺癌腋窝淋巴结转移预测 发表期刊:Ann Transl Med 作...
(18)f-fdg-pet_ct for systemic staging of newly diagnosed triple-negative breast cancer.(18)f-fdg-pet_ct系统性的新诊断为三阴性乳腺癌 热度: triple-negative breast cancer new perspectives for targeted therapies:三阴性乳腺癌新的靶向治疗的观点 ...
Tumour heterogeneity and a long-standing paucity of effective therapies other than chemotherapy have contributed to triple-negative breast cancer (TNBC) being the subtype with the least favourable outcomes. In the past few years, advances in omics technologies have shed light on the relevance of the...
Triple-negative breast cancer (TNBC) is seen as a highly invasive BC, characterized by a short survival, higher mortality, recurrence, and metastasis when it is compared to the other BC subtypes. The molecular subtyping of TNBC based on mRNA expression levels does not accurately reflect protein ...
Triple negative breast canceris a very aggressive breast cancer subtype which has not been characterized well enough and for this reason it is often fatal.MicroRNAshave the potential to act as therapeutic targets and thus, it is essential that further research is conducted to shed light on their...
However, the mechanism by which PKM2, as a histone kinase, regulates the transcription of genes involved in triple-negative breast cancer (TNBC) metastasis remains poorly understood. Methods We integrated cellular analysis, including cell viability, proliferation, colony formation, and migration assays;...
Triple-negative breast cancer (TNBC) is defined by a lack of expression of estrogen receptors (ER), progesterone receptors (PR), and an amplification or overexpression of human epidermal growth factor receptor type 2 (HER2), and accounts for 10–15% of breast cancer cases [1,2]. TNBC is ...