Enhanced neovasculogenesis, especially vasculogenic mimicry (VM), contributes to the development of triple-negative breast cancer (TNBC). Breast tumor-initiating cells (BTICs) are involved in forming VM; however, the specific VM-forming BTIC population and the regulatory mechanisms remain undefined. W...
Triple negative breast cancerImmunogenic cell deathImmunoadjuvantα5β1-targeted micellar paclitaxel (ATN-MPTX) shows high selectivity and strong ICD in murine 4T1 cells.ATN-MPTX diaplays superior inhibition of metastatic 4T1 tumor to free PTX and MPTX.ATN-MPTX plus nano-STING agonist augments ...
TME: Tumor microenvironment TNBC: Triple negative breast cancer TNF-α: Tumor necrosis factor-α Treg: Regulatory T cells TriTNE: Nanotechnology × PD-L1/CD3 three specific T cell nano adapter TROP2: Trophoblast cell surface antigen 2 VEGF: Vascular endothelial growth factor ...
Triple-negative breast cancer (TNBC) is recognized as a particularly aggressive subtype of breast cancer that is devoid of effective therapeutic targets. Immune checkpoint inhibitors (ICIs) have demonstrated promising results in TNBC treatment. Nonethele
Enhanced neovasculogenesis, especially vasculogenic mimicry (VM), contributes to the development of triple-negative breast cancer (TNBC). Breast tumor-initiating cells (BTICs) are involved in forming VM; however, the specific VM-forming BTIC population and the regulatory mechanisms remain undefined. ...
The combination of programmed cell death ligand-1 (PD-L1) immune checkpoint blockade (ICB) and immunogenic cell death (ICD)-inducing chemotherapy has shown promise in cancer immunotherapy. However, triple-negative breast cancer (TNBC) patients undergoing this treatment often face obstacles such as sy...
Background: Triple negative breast cancer (TNBC) is the most aggressive breast cancer subtype, represents 10%-20% of all breast cancers and occurs more frequently in young Non- Hispanic Black and Latina women. TNBC is highly immunogenic due to the relatively high levels of tumor infiltrating ...
Triple-negative breast cancer (TNBC) still lacks effective treatment options due to tumor heterogeneity and immunosuppressive microenvironment caused chemoimmunotherapy therapy resistance. Here, the programmed death ligand-1 (PD-L1) and AXL protein are observed to be overexpressed in the paclitaxel (PTX)...
Breast cancer Polypyrrole nanoparticle Hyaluronic acid Photothermal therapy Triple-combination therapy 1. Introduction Breast cancer is the most common malignancy in women worldwide, with low survival rate [1]. Especially, the triple-negative breast cancer (TNBC) subtype is characterized by higher aggress...
Fig. 4: eIF4E promotes RIPK1-dependent necroptosis-mediated VM formation in triple-negative breast cancer. A,BThree-dimensional tube formation showing that eIF4E expression promoted VM formation. SH-eIF4E MDA-MB-231, EX-eIF4E MCF-7, and control cells for 3D Matrigel culture (bar = 100 ...