Acetoacetyl CoA thiolase is very active in the mitochondria and supernatant of adipose tissue. Our results show that, in mice adipose tissue in particular, where the citrate-cleavage enzyme is not very active, acetyl CoA is probably transformed into acetoacetate so that it can leave the ...
The increase in autophagic flux mediated by SGLT2 inhibitors also promotes the clearance of harmful glucose and lipid by-products and the disposal of dysfunctional mitochondria, allowing for mitochondrial renewal through mitochondrial biogenesis. This Review describes the orchestrated interplay between ...
Import of fatty acids to cardiac cells. Upon uptake, fatty acids (FAs) are converted to acyl-CoA by acyl-CoA synthetase. Short- and medium-chain (SC and MC, respectively) acyl-CoA enter mitochondria for FA β-oxidation (FAO). Long chain (LC) acyl-CoA is imported into mitochondria via ...
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the acyl aminocarnitines are used as competitive inhibitors of carnitine acyl transferase and acyl compounds as intermediates for the manufacture of the acylated compounds. GRIFFITH Owen W. - WO 被引量: 17发表: 1985年 Acetyl-carnitine formation and pyruvate oxidation in mitochondria from different ra...
This type of mechanism implies of a ternary complex of the carrier with one internal and one external substrate molecule before the reaction occurs. 展开 关键词: CARNITINE CARRIER TRANSPORT MECHANISM (BRAIN, MITOCHONDRIA 被引量: 28 年份: 1995 ...
(a) Describe the structure of the Golgi apparatus. (b) Describe its function. What are the mechanisms of Virus Cell-to-Cell Transmission? State with references. Describe the transport of fatty acyl-CoA molecules from the cytoplasm into the mitochondria and discuss the role of carnitine in media...
bioenergetics, a lack of fitness defect of the SLC25A32 KOs in galactose when cells depend on respiration for survival (Fig.2cand Supplementary Fig.2f) is surprising, and indicates that either SLC25A32 does not transport FAD into mitochondria in K562 cells, or perhaps that redundant ...
The BCKDH complex is inhibited by NAD(H) and branched-chain-acyl-CoA (90). BCAAs bypass the liver, owing to lack of mitochondrial branched-chain aminotransferase (BCATm) in this tissue. This allows leucine to be a more powerful activator of mTORC1 (mechanistic target of rapamycin complex ...