Sanchez LB, Galperin MY, Mu¨ ller M (2000) Acetyl-CoA synthe- tase from the amitochondriate eukaryote Giardia lamblia be- longs to the newly recognized superfamily of acyl-CoA synthetases (nucleoside diphosphate-forming). J Biol Chem 275:5794-5803...
Acetyl-CoA may seem to be ubiquitous because of its role in so many processes. However, in some aged cells and mostcancer cells, some of the machinery that makes and uses acetyl-CoA is dysfunctional or broken. In particular, mitochondria are responsible for the production of acetyl-CoA from...
biotin carboxylase and carboxyltransferase. ACC2 is throught to control fatty acid oxidation by the means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I (CPT-1), the rate-limiting step in fatty acid uptake and oxidation by mitochondria (2). The activity of ACC...
The acetyl-CoA produced by mitochondrial beta-oxidation of fatty acids enters the Kreb's cycle to produce energy, but that is not the only fate of acetyl-CoA. In liver mitochondria, some acetyl-CoA is converted to acetoacetate, beta-hydroxybutyrate, and acetone, collectively called ketone bodies...
Although mitochondria are ubiquitously present throughout the wing disc (mitochondrially targeted GFP (mitoGFP) signals; Fig. 5a), the MMP was high only in a proximal region of the wing disc that was broader than the H3K18achigh region (Fig. 5a). The TMRM signal was lost following ...
Here we demonstrated that in BLCA cells, ACSS3 is localized in mitochondria and functions as an oncogene to promote lipid synthesis and histone acetylation through the use of acetate. Importantly, our data showed that the expression level of ACSS3 were significantly upregulated in BLCA cell ...
biotin carboxylase and carboxyltransferase. ACC2 is throught to control fatty acid oxidation by the means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I (CPT-1), the rate-limiting step in fatty acid uptake and oxidation by mitochondria (2). The activity of ACC...
acetyl coa 美 英 un.乙酰辅酶A 网络乙醯辅酶;乙醯辅脢;乙醯辅酶A 英汉 网络释义 un. 1. 乙酰辅酶A
from the cytosol. The transport of pyruvate into the mitochondria is via a transport protein and is active, consuming energy. On entry to the mitochondria pyruvate decarboxylation occurs, producing acetyl CoA. This irreversible reaction traps the acetyl CoA within the mitochondria. Pyruvate dehydrogenase...
, the function of ACAC is to regulate the fatty mechanism. When the enzyme is active, the product, malonyl-CoA is produced and inhibit the transfer of the fatty acyl group from acyl CoA tocarnitinewith carnitine acyltransferase, which inhibits thebeta-oxidationof the fatty acid inmitochondria....