The heart has a high energy demand due to its contractile function and relies primarily on mitochondrial fatty acid oxidation for energy production [88]. Notably, free fatty acids (FFAs), as a source of energy for heart muscle, are less effective because they require approximately 10% more oxy...
Importantly, GPX4, as a central regulator of ferroptosis, connects other cellular molecules and pathways with ferroptosis. Acyl-CoA synthetase long-chain family member 4 (ACSL4) is involved in cell ferroptosis sensitivity, and directly incorporates long-chain polyunsaturated fatty acids (PUFAs) into p...
2000. Acetyl-CoA synthetase from the amitochondriate eukaryote Giardia lamblia belongs to the newly recog- nized superfamily of acyl-CoA synthetases (nucleoside diphosphate- forming). J. Biol. Chem. 275:5794 -5803. http://dx.doi.org/10.1074/jbc .275.8.5794....
Full size image Acetyl-CoA can be generated from oxidative decarboxylation of pyruvate from glycolysis, and β-oxidation of fatty acids. Both glycolysis and β-oxidation are regulated by HIF. HIF increases the expression of pyruvate dehydrogenase kinase (PDK) 1 and PDK4, which phosphorylate and th...
Inhibition of Fatty Acid Translocase (FAT/CD36) Palmitoylation Enhances Hepatic Fatty Acid β-Oxidation by Increasing Its Localization to Mitochondria and Interaction with Long-Chain Acyl-CoA Synthetase 1. Antioxid Redox Signal. 2022;36:1081–100. Article CAS PubMed Google Scholar Ioannou GN. The...
The impact of fatty acid oxidation on energy utilization: targets and therapy. Curr Pharm Des 2002; 8: 1199–1227. Article CAS Google Scholar Poppelreuther M, Rudolph B, Du C, Grossmann R, Becker M, Thiele C et al. The N-terminal region of acyl-CoA synthetase 3 is essential for ...
One of the most common proteins used as a MAM marker is long chain acyl-coA synthetase (ACSL4/FACL4), which mediates the ligation of fatty acids to coenzyme A and other cholesterol metabolites [27]. Localization of ACSL4 in MAM and its important role on mitochondrial fusion has been ...
他们研究了磷脂酶C 抑制剂苯甲基磺酰氟对大鼠脑线粒体缺血性损伤的作用。 4. Why isn´t the fatty acyl coa transported into themitochondriadirectly? 为什么不将脂酰辅酶 A 直接运输到线粒体中? 5. They don’t havemitochondria. 这些生物没有线粒体。 单词专题...
HIF-1-mediated suppression of acyl-CoA dehydrogenases and fatty acid oxidation is critical for cancer progression. Cell Rep. 2014;8:1930–42. Article CAS PubMed Google Scholar Krishnan J, Suter M, Windak R, Krebs T, Felley A, Montessuit C, et al. Activation of a HIF1alpha-PPARgamma ...
Fatty acid transport protein 4 is the principal very long chain fatty acyl-CoA synthetase in skin fibroblasts J Biol Chem, 282 (2007), pp. 20573-20583 CrossrefView in ScopusGoogle Scholar 28 J.R. Friedman, L.L. Lackner, M. West, J.R. DiBenedetto, J. Nunnari, G.K. Voeltz ER tubul...