The confidence that flowed from these early triumphs resulted in the development of a grand universal theory, called the central dogma of molecular biology—namely, that all cells (and hence viruses) work on a simple organizing principle: the unidirectional flow of information from DNA, through ...
Biochemistry, Genetics and Molecular Biology Immunology and Microbiology Medicine and DentistryDiscover other topics On this page Chapters and Articles Related Terms Recommended Publications Chapters and Articles You might find these chapters and articles relevant to this topic. Effects of propofol ...
Transcription termination is a crucial step in the production of conforming mRNAs and functional proteins. Under cellular stress conditions, the transcription machinery fails to identify the termination site and continues transcribing beyond gene boundar
we categorized these 2,179 motifs into 282 motif clusters, a classification determined by position weight matrix similarity. Using this established clustering definition, we eliminated redundant nucleotide-level motif matches
Remarkably, while other bZIP sub- families are mainly involved in simple homo- or quasi-homodimerization events (i.e. dimerization between close paralogs)30, C/S1 interactions give rise to a more complex dimerization network, as shown in the model species arabidopsis (Arabidopsis thaliana)13,14....
Metazoan cells only utilize a small subset of the potential DNA replication origins to duplicate the whole genome in each cell cycle. Origin choice is linked to cell growth, differentiation, and replication stress. Although various genetic and epigenetic signatures have been linked to the replication...
The regulation of genes in multicellular organisms is generally achieved through the combinatorial activity of different transcription factors. However, the quantitative mechanisms of how a combination of transcription factors controls the expression of
Definition of intron/exon structures within the MYB domains The observed intron distribution, positions, and phases within each subfamily are shown in Figure3andAdditional file 3. In order to determine the numbers and positions of exons and introns within each soybean MYB gene, we compared the ful...
Transcription in eukaryotes is more complicated than in prokaryotes. First, the RNA polymerase of higher organisms is a more complicated enzyme than the relatively simple five-subunit enzyme of prokaryotes. In addition, there are many more accessory factors that help to control theefficiencyof the in...
The translation is the third step in the central dogma ofmolecular biology. In the previous two steps of DNA replication andDNA transcriptionto RNA, the encoded information is in the language of fournitrogenous baseswhich areadenine,thymidine(uracil in RNA),guanosine, andcytosinebecause both DNA an...