The term transcription came from Latin transcriptiōnem, from trānscrībō, meaning “transcribe”. Central dogma The central dogma of molecular biology holds that the genetic information flows from DNA to DNA through the replication and from DNA to mRNA through transcription. mRNA is translated (tra...
(Table 1). Interestingly, α-amanitin produced byAmanita phalloides, the Death Cap mushroom, affects the three polymerases very differently. RNA polymerase I is completely insensitive to α-amanitin, meaning that the polymerase can transcribe DNA in vitro in the presence of this poison. In ...
MartinFranke,José LuisGómez-Skarmeta, inCurrent Opinion in Cell Biology, 2018 Introduction Gene transcription is regulated bycis-regulatory elements (CREs) that can be found at large distances from the genes they control [1,2,3•]. The genome territory containing allCREsregulating a particular...
As discussed earlier the just hatched squids (hatchlings) are symbiotic, meaning that they are not in association with the bioluminescent bacteria V. fischeri and are yet to possess the bacteria (Wei & Young, 1989). V. Fischeri, which is a marine bacterium present abundantly in the seawater...
Organisms determine the transcription rates of thousands of genes through a few modes of regulation that recur across the genome1. In bacteria, the relationship between the regulatory architecture of a gene and its expression is well understood for indiv
Finally, this review discusses the major challenges that need to be resolved and knowledge gaps in the biology that need to be filled in this research field and suggests SEs frontiers in clinical practice. Characteristics of super-enhancers With cell-specific characteristics and physiologically ...
Therefore, it is of great meaning to explore effective molecular targets for GBM treatment. G protein family is considered to be a vital regulator in cancer progression, which can serve as potential targets for cancer treatment6,7. G protein subunit Gamma 5 (GNG5) is a member of the G ...
In free or loose translation, the objective is to convey the meaning of the content in a way that would be easier for the target readers to understand. More Connections Get this – they use both these terms in biology too. It ties back to DNA and its functions. Transcription changes the...
We discussed the potential role of these factors in myelomagenesis and myeloma biology. The specific targeting of these factors might constitute a new therapeutic strategy in multiple myeloma. Abstract Plasma cells (PCs) have an essential role in humoral immune response by secretion of antibodies, ...
In an informational sense,nucleobasesand nucleotides have the same meaning. Bases in one and the other chain are connected in a complementary way makingbase pairsA-T and C-G. In the human DNA, there are about 3 × 109basepairs and about 20,000 protein-coding genes. In addition to ...