定义:transcription factor binding site(TFBS) TFBS指的是TF特异结合的DNA分子的position(位置),延伸的话,就是DNA片段的序列边界。 注意,文献中经常把结合位点和结合域混淆(binding site ,binding motif) 我们推荐保留“site”这个词来定义某一特别sequence(基因的或artificial),这是一个factor结合的地方。而“motif”...
The eukaryotic upstream binding factor (DBF), recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA poly-merase I through cooperative interactions with the species-specific factor, SL1. Isolation of complementary DNA clones and sequence analysis reveals similarities between ...
(57) [summary] protein was isolated, including the winged helix motif with a potential capacity to bind to (i) nucleic acid, and Cys -His zinc finger motif with a nucleic acid binding capacity again (ii) , and nucleic acid molecules encoding the same are disclosed.アリソンヒラリーバナ...
The results indicated that PEG3 likely functions as a transcriptional repressor for these two loci. Overall, the current study provides a set of genomic targets and also redefines the DNA-binding motif for the imprinted transcription factor PEG3. 展开 ...
Whole-genome deep sequencing-based analysis has revealed unexpectedly rich relationships between inherited epigenetic states, transcription factor–DNA binding affinity thresholds and influences of given transcription factors on the activities of other factors in the same cells. Together, these mechanisms ...
CompleteMOTIFs: DNA motif discovery platform for transcription factor binding experiments . Bioinformatics 27 :715–717. doi:.10.1093/bioinformatics/btq707 [ ... L Kuttippurathu,M Hsing,Y Liu,... - 《Bioinformatics》 被引量: 67发表: 2010年 iMOTIF: an integrative MOTIF discovery platform for ...
2013. DNA-binding motif and target genes of the imprinted transcription factor PEG3. Gene, 512, 314-20.Thiaville MM, Huang JM, Kim H, Ekram MB, Roh TY, et al. (2013) DNA- binding motif and target genes of the imprinted transcription factor PEG3. Gene 512: 314-320....
本文提介绍了scFAN(single-cell factor analysis network单细胞因子分析网络),这是一种深度学习模型,可以预测单个细胞中全基因组的转录因子结合网络。 scFAN包括对大量的数据进行“预训练模型”训练,然后使用DNA序列数据,汇总的相似scATAC-seq数据和可定位性数据的组合,将其用于预测单细胞水平上的转录因子结合。
For the remaining 32 TFs, we found that 88% (28/32) of factors significantly (P < 10−75) associate with the known DNA binding motif. Moreover, we carried out de novo motif discovery for these factors (using MEME40 and Homer38) and show that these motifs are highly similar to the...
F. et al. Quantitative analysis of the DNA methylation sensitivity of transcription factor complexes. Cell Rep. 19, 2383–2395 (2017). This comprehensive in vitro study shows that methylation sensitivity of a TF can be a function of binding motif sequence variants. Article CAS PubMed PubMed ...