Modulating transcription factor activity: Interfering with protein-protein interaction networksDevelopmental biologyTranscription factorProtein-protein interactionsNetworkRedundancySmall compoundsDrug developmentBiophysical parameters that govern transcription factors activity are binding locations across the genome, dwelling...
The most common model used to represent TF binding specif... E Sharon,S Lubliner,E Segal - 《Plos Computational Biology》 被引量: 217发表: 2008年 Direct protein–protein interaction between the intracellular domain of TRA-2 and the transcription factor TRA-1A modulates feminizing activity in C...
regulate neuronal disorders. Activation of AP1 transcription factor is an important signaling event activated by the LDAs. HNE-mediated cytotoxicity has been linked to enhanced AP1 nuclear binding activity in hepatic stellate cells, pancreatic cells, neuronal cells, fibroblasts, human hematopoietic st...
The RNA-binding protein FPA regulates flg22-triggered defense responses and transcription factor activity by alternative polyadenylation 来自 Semantic Scholar 喜欢 0 阅读量: 98 作者: R Lyons,A Iwase,Thomas Gnsewig,A Sherstnev,C Duc,GJ Barton,K Hanada,M Higuchi-Takeuchi,M Matsui,K Sugimoto 展开...
Sm-like protein Rof inhibits transcription termination factor ρ by binding site obstruction and conformational insulation Said et al. used cryoEM, biochemistry and bioinformatics to uncover how the Sm-like protein Rof regulates transcription termination. Rof binds termination factor ρ, inhibiting ρ ...
A cell-based assay system for monitoring NF-kappaB activity in human HaCat transfectant cells. Anal Biochem 292, 17–21 (2001). Article CAS PubMed Google Scholar Libermann, T. A. & Baltimore, D. Activation of interleukin-6 gene expression through the NF-kappa B transcription factor. Mol ...
Although repetitive DNAs are not typically considered as regulatory elements that directly affect transcription, they can contain binding sites for some transcription factors. Here, we demonstrate that binding of the transcription factor CCAAT/enhancer-binding protein alpha (C/EBPalpha) to the mouse ...
(NO)inventricularcardiomyocytesoftherat.Wefocusedonmembersofthemitogen-activatedproteinkinase(MAPK)familyandtheirdownstreamtarget,thetranscriptionfactorAP-1.PRINCIPALFINDINGS1.NOinducesapoptosisviaAP-1activationincardiomyocytesTotestwhetherNOactivatesthetranscriptionfactorAP-1incardiomyocytes,bindingactivityofAP-1in...
Transcription factor, molecule that controls the activity of a gene by determining whether the gene’s DNA is transcribed into RNA. Transcription factors control when, where, and how efficiently RNA polymerases, which catalyze the reactions that synthesi
The p48 DNA-binding subunit of transcription factor PTF1 is a new exocrine pancreas-specific basic helix-loop-helix protein. We report the isolation of cDNA for the p48 DNA-binding subunit of the heterooligomeric transcription factor PTF1. A sequence analysis of the cDNA demonstr... A Krapp...