which is a sensitive live-cell imaging method to measure the interaction of CSB with lesion-stalled Pol II46. CSB–mScarlet-I FRAP showed strong and dose-dependent immobilization after FA treatment, with 300 µM of FA resulting in a similar CSB immobilization level as ...
DNA–protein crosslinks (DPCs) induced by aldehydes interfere with replication and transcription. Hereditary deficiencies in DPC repair and aldehyde clearance processes cause progeria, including Ruijs–Aalfs syndrome (RJALS) and AMeD syndrome (AMeDS) in
The TGF-β signaling pathway is a fundamental pathway in the living cell, which plays a key role in many central cellular processes. The complex and sometimes contradicting mechanisms by which TGF-β yields phenotypic effects are not yet completely under
Transcription is a complex and dynamic process representing the first step in gene expression that can be readily controlled through current tools in molecular biology. Elucidating and subsequently controlling transcriptional processes in various prokaryotic and eukaryotic organisms have been a key element in...
- 《Molecular Biology Reports》 被引量: 17发表: 2014年 Genome-wide investigation of the NAC transcription factor family in melon (Cucumis melo L.) and their expression analysis under salt stress Genome-wide investigation of the NAC transcription factor family in melon (Cucumis melo L.) and ...
Find a journal Publish with us Track your research Search Cart Home BMC Plant Biology Article Genome-wide identification and expression pattern analysis of R2R3-MYB transcription factor gene family involved in puerarin biosynthesis and response to hormone in ...
Association of fungal secondary metabolism and sclerotial biology. Fungal secondary metabolism and morphological development have been shown to be intimately associated at the genetic level. Much of the literature has focu... M Ana,Calvo,W Jeffrey,... - 《Frontiers in Microbiology》 被引量: 35发表...
steps of second-generation sequencing technologies [6,7]. It is apparent that single-molecule long reads that capture the entire RNA molecule can offer a better understanding of the rich patterns of alternative transcription initiation and mRNA processing events and, hence, the underlying biology. ...
Here, the authors define the early transcriptional response to acute hypoxia and identify HIF1A target genes as part of this acute response, providing a resource for investigating context-dependent roles of HIF1A in the biology of cancer. Zdenek Andrysik , Heather Bender & Joaquin M. Espinosa ...
Nature Structural & Molecular Biology volume 30, pages 1958–1969 (2023)Cite this article 20k Accesses 18 Citations 170 Altmetric Metrics details Abstract Transcription factors are among the most attractive therapeutic targets but are considered largely ‘undruggable’ in part due to the intrinsically ...