which is a sensitive live-cell imaging method to measure the interaction of CSB with lesion-stalled Pol II46. CSB–mScarlet-I FRAP showed strong and dose-dependent immobilization after FA treatment, with 300 µM of FA resulting in a similar CSB immobilization level as ...
A global analysis of sex-biased transcription inDrosophilashows extensive differential expression between the sexes. Most sex-differential expression is du... M Parisi,R Nuttall,P Edwards,... - 《Genome Biology》 被引量: 519发表: 2004年 Rapid and sensitive reporter gene assays for detection of ...
Here, the authors define the early transcriptional response to acute hypoxia and identify HIF1A target genes as part of this acute response, providing a resource for investigating context-dependent roles of HIF1A in the biology of cancer. Zdenek Andrysik , Heather Bender & Joaquin M. Espinosa ...
BMC Systems Biology volume 8, Article number: 55 (2014) Cite this article 9852 Accesses 26 Citations 2 Altmetric Metrics details Abstract Background The TGF-β signaling pathway is a fundamental pathway in the living cell, which plays a key role in many central cellular processes. The complex...
We discussed the potential role of these factors in myelomagenesis and myeloma biology. The specific targeting of these factors might constitute a new therapeutic strategy in multiple myeloma. Abstract Plasma cells (PCs) have an essential role in humoral immune response by secretion of antibodies, ...
Besides this well-described role in normal development and carcinogenesis, increasing evidence further indicates that HOXA5 is highly expressed in the adipose tissue (AT) and plays an active role in regulating adipocyte biology and body fat distribution [8]. Changes in HOXA5 expression correlate with...
qRT-PCR is a laboratory technique based on the PCR which is used to amplify and simultaneously quantify a targeted DNA molecule. From: Clinica Chimica Acta, 2011 About this pageAdd to MendeleySet alert Also in subject areas: Biochemistry, Genetics and Molecular Biology Food Science Immu...
AlessandroBisello,Peter A.Friedman, inPrinciples of Bone Biology (Third Edition), 2008 Transcription Factors A major effect ofPTHandPTHrPin osteoblasts is directed to modulating the expression and/or function of a number of transcription factors known to be important inbone metabolism. Among the...
Organisms determine the transcription rates of thousands of genes through a few modes of regulation that recur across the genome1. In bacteria, the relationship between the regulatory architecture of a gene and its expression is well understood for individual model gene circuits2,3. However, a broa...
(HATs and HDACs) appeared to be highly expressed whereas others showed a low level of expression. As expected, high expression of every histone transcript, corresponding to the most abundant proteins encountered in eukaryote nuclei, (eight annotated in PlasmoDB) was also observed and maximal ...