Treg cells are generally divided into two main groups: 1) CD25+ Foxp3+ CD4+ T cells (Foxp3+ Treg cells) and 2) IL-10-producing Foxp3? CD4+ T cells (Tr1 cells). We demonstrated that the number of Tr1 cells in peripheral blood mononuclear cells in SCIT-treated pollinosis patients were...
In summary, CAF16 regulates not only de novo generation of Th17 cells, but also preexisting Th17 responses in an antigen-specific manner, while Th1- and FoxP3+ Treg-responses are unaffected. 2.3. CAF16-promoted exTh17 cells display distinct markers associated with immune regulation Our results ...
Our findings suggested that proinflammatory M1 macrophages and Tfh cells were increased, while the anti-inflammatory Treg and Tr1 cells were decreased and the imbalance of these cells and their releasing cytokines contributed to progression in atherosclerosis with SLE. Further studies may validate these ...
Conclusion The expression imbalance of Treg cells (especially Tr1 cells) a d Th17 cells in CHB patients is positively correlated with the progression of the disease; therefore, it may be important to correct the expression imbalance of Treg cells and Th17 cells in the treatment of CHB. ...