[1] Yang, Soo Jung et al. “Pancreatic islet-specific engineered Tregs exhibit robust antigen-specific and bystander immune suppression in type 1 diabetes models.” Science translational medicine vol. 14,665 (2022): eabn1716. doi:10.1126/scitranslmed.abn1716 [2] New T-Cell Therapy May Treat...
Selective IL-2 responsiveness of regulatory T cells through multiple intrinsic mechanisms supports the use of low-dose IL-2 therapy in type 1 diabetes. Diabetes 64, 2172–2183 (2015). Article CAS PubMed Google Scholar Grinberg-Bleyer, Y. et al. IL-2 reverses established type 1 diabetes ...
today announces that its polyclonal Treg cell therapy PTG-007 demonstrated significant insulin secretion restoration in early-onset type-1 diabetes (T1D) patients, as well as a longer period of disease
具体策略包括:(1)赋予均一的抗原特异性,如表达特定的T细胞受体(T cell receptors,TCRs)或嵌合抗原受体(chimeric antigen receptors,CARs);(2)改变优势分子表达,如功能相关分子或细胞因子(如IL-10)或促进Treg稳定性的蛋白[如同源性磷酸酶与张力蛋白(Phosphatase and ten...
The frequency of follicular regulatory T (Tfr) cells, a type of eTregs, is significantly higher and correlates with negative prognosis in numerous tumors. Meanwhile, higher tumoral Tfr cell signatures put melanoma at increased risk of metastasis [61,62]. Tfr cells modulated by Blimp1 hinder germ...
cell-surface il-7 receptor expression facilitates the purification of foxp3(+) regulatory t cells.trends immunol 27:541–544. macdonald kn, piret jm, levings mk (2019) methods to manufacture regulatory t cells for cell therapy.clin exp immunol 197:52–63. akkaya b, holstein ah, isaac c ...
The imbalance in immune tolerance may cause the variety of reproductive failures. An intravenous immunoglobulin infusion (IVIg) therapy is used to improve the live birth rate in women suffering from recurrent pregnancy loss, recurrent spontaneous abortio
autoimmune therapy,all in one hand The largest, most advanced pipeline of cell therapies for autoimmune disease. Company deck AboutPolTREG Three clinical assets that will deliver value and milestones PTG007, a potential disease-modifying treatment for Type-1 Diabetes and Multiple Sclerosis ...
Cell therapy (DC, Treg, NKT) (WS-040) Chairpersons: Toshinori Nakayama, Jay Berzofskydoi:10.1093/intimm/dxq303J. J. O'KonekP. IllarionovD. Stewart KhursigaraE. AmbrosinoB. F. CastilloR. RajuM. KhaliliH. KimA. R. HowellG. S. Besra...
Another embodiment is the finding that stimulation of stem cell activation results in stem cell secondary activation of immune modulatory cells, one type which is T regulatory cells (Tregs). One specific embodiment involves extraction of a heterogenous stem cell pool, which contains T regulatory ...