GNTI-122: an autologous antigen-specific engineered Treg cell therapy for type 1 diabetesdoi:10.1172/jci.insight.171844Tregs have the potential to establish long-term immune tolerance in patients recently diagnosed with type 1 diabetes (T1D) by preserving 尾 cell function. Adoptive transfer of ...
具体策略包括:(1)赋予均一的抗原特异性,如表达特定的T细胞受体(T cell receptors,TCRs)或嵌合抗原受体(chimeric antigen receptors,CARs);(2)改变优势分子表达,如功能相关分子或细胞因子(如IL-10)或促进Treg稳定性的蛋白[如同源性磷酸酶与张力蛋白(Phosphatase and ten...
[26]Koch M A, Tucker H G, Perdue N R, et al. The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation[J]. Nature Immunology,2009,10(6):595-602. [27]Oldenhove G, Bouladoux Nwohlfert E A. Decrease of Foxp3+ Treg cell number and...
具体策略包括:(1)赋予均一的抗原特异性,如表达特定的T细胞受体(T cell receptors,TCRs)或嵌合抗原受体(chimeric antigen receptors,CARs);(2)改变优势分子表达,如功能相关分子或细胞因子(如IL-10)或促进Treg稳定性的蛋白(如同源性磷酸酶与张力蛋白[Phosphatase and ...
Selective IL-2 responsiveness of regulatory T cells through multiple intrinsic mechanisms supports the use of low-dose IL-2 therapy in type 1 diabetes. Diabetes 64, 2172–2183 (2015). Article CAS PubMed Google Scholar Grinberg-Bleyer, Y. et al. IL-2 reverses established type 1 diabetes ...
CellTrace染料 细胞分裂 CD25流式抗体 活化标志物 CD134流式抗体 活化标志物 Brdu / EdU 细胞增殖检测 DNA合成/增殖 3H-胸苷 DNA合成/增殖 Treg调节性T细胞因子谱 Treg调节性T细胞已通过多种方法被证明可以抑制T细胞的功能,机制包括接触依赖和细胞因子介导。其中包括TGF-b的分泌,它已被证明能强有力的抑制效应T细...
LSD1 inhibition improves efficacy of adoptive T cell therapy by enhancing CD8+ T cell responsiveness Article Open access 27 August 2024 Data availability scRNA-seq data have been deposited in the GEO database under accession code GSE223930. ATAC-seq and CUT&RUN-seq data have been deposited ...
2022年1月7日,Nature Reviews Clinical Oncology(IF: 66.675)杂志上发表了一篇题为“Harnessing cytokines and chemokines for cancer therapy”的综述 [1]。在本文中,作者谈到了趋化因子受体阻断的临床试验用于治疗恶性肿瘤的巨大潜力。同样引起关注的是,CCR4作为关键的肿瘤相关的趋化因子受体,在一项涉及实体肿瘤患者的I...
近日,美国加利福尼亚大学的Michel DuPage研究团队在Immunity杂志在线发表题为CXCR3 expression in regulatory T cells drives interactions with type I dendritic cells in tumors to restrict CD8+ T cell antitumor immunity的研究文章。该论...
IL-18 binding protein suppresses IL-17-induced osteoclastogenesis and rectifies type 17 helper T cell/regulatory T cell imbalance in rheu‐ matoid arthritis[J]. J Transl Med,2021,19(1):392. [23] ZHANG H,YIN L,LU M,et al. Evodiamine attenuates adjuvant-induced arthritis in rats by ...