Selective IL-2 responsiveness of regulatory T cells through multiple intrinsic mechanisms supports the use of low-dose IL-2 therapy in type 1 diabetes. Diabetes 64, 2172–2183 (2015). Article CAS PubMed Google Scholar Grinberg-Bleyer, Y. et al. IL-2 reverses established type 1 diabetes ...
20.00 ± 1.61%, p = 0.034) in iTreg cells induced in vitro compared to wild-type mice. Mice with Treg cell-specific PI16 ablation are protected from autoimmune arthritis (AIA) and dextran sulfate sodium (DSS)-induced colitis development. The AIA model of PI16CKO is characterized...
The most prevalent motifs belong to the activator protein 1 (AP-1) transcription factor subfamily, part of the basic leucine zipper (bZIP) family (Supplementary Fig. 5d) indicating this subfamily is crucial in driving the eTreg cell signature, as similarly proposed by DiSpirito et al.54 for ...
1. Introduction Obesity-related chronic low-grade inflammation is a potential trigger for comorbidities, such as insulin resistance (IR) and type 2 diabetes (T2D) [1]. Weight gain caused by excessive food intake, physical inactivity, and poor diets, leads to adipose tissue (AT) expansion due ...
Regulatory T cells (Tregs) induce immune responses and may contribute to immune escape in tumors. Accumulation of Tregs in tumors represents a critical barrier to anti-tumor immunity and immunotherapy. However, conflicting results describing the role of
ParkHJ, ParkJS, JeongYH, et al.PD-1 upregulated on regulatory T cells during chronic virus infection enhances the suppression of CD8+T cell immune response via the interaction with PD-L1 expressed on CD8+T cells[J]. J Immunol, 2015, 194...
Propofol is widely used in clinical anesthesia due to its advantages of rapid onset and less adverse reactions. This study focused on the role of propofol in the balance of Th17/Treg in elderly patients with lung cancer during perioperative period. Patie
但过度表达的 mTOR 会抑制 Treg, 短暂的 TCR 刺激会诱导激活 PI3K/Akt/mTOR 信号通路, 拮抗 FoxP3 的表达[35].mTOR-HIF1 轴可以促进 FoxP3 的降解和转录因子 RORγt 的活性, 进而 直接调控可诱导性 Treg 细胞(inducible regulatory T cell,iTreg) 和 Th17 细胞的分化[36].mTOR 通 路激活后会抑制 FoxP...
1c). We next asked whether the lack of αPD1 therapy efficacy was associated with increased Treg cell anergy in GBM. In contrast to peripheral tumors where αPD1 therapy can lead to an increased Treg cell frequency in tumors39,αPD1 therapy in GBM did not significantly alter Treg cell ...
Treg nTreg cells cells (derived from to the tumour site, both contributing to the pool of tumour-associated Treg cells. During resolution of inflammation, T helper type 17 (Th17) cells were shown to transdifferentiate into another regulatory T-cell subset, IL10 þ T regulatory type 1 (Tr1...