在一项对小鼠进行的新研究中,他们指出免疫细胞的一个亚群——1型调节性T细胞(type 1 regulatory T cell, Tr1细胞),在防止免疫系统过度反应方面发挥了正常作用,但却在无意中抑制了免疫疗法的抗癌能力。相关研究结果发表在2024年8月1日的Nature期刊上,论文标题为“Neoantigen-specific cytotoxic Tr1 CD4 T cells suppre...
耐受性树突状细胞 耐受性树突状细胞(Dendriticcells,DC)是维持免疫稳态、抑制免疫反应、促进免疫耐受的关键细胞亚群。DC-10是以HLA-G和ILT-4表达为特征,产生人白细胞介素-10(IL-10)的耐受性群体,在通过1类调节型T1细胞(TR1)促进耐受。 到目前为止,由于缺乏唯一识别DC-10的标记...
2024年8月1日,国际知名学术期刊《Nature》发表了一项令人瞩目的研究成果,题为“Neoantigen-specific cytotoxic Tr1 CD4 T cells suppress cancer immunotherapy”。该研究由华盛顿大学医学院的Robert D. Schreiber博士团队主导,揭示了免疫系统中一种名为Tr1的CD4+ T细胞在癌症免疫疗法中的意外抑制作用,并探索了克服这一障...
Many cell subsets with regulatory function have been described, including natural CD4+CD25+Foxp3+ T cells and acquired regulatory T cells such as regulatory type I cells (Tr1) or Th3 cells. They are generated from different precursors and have different mechanisms of action. Tr1 cells are ...
Abdolmohamad Rostami教授发现BBI可以通过IFN-g/STAT1途径来促进Tr1细胞的产生,进而可以有效控制自身免疫炎症。特别是这一过程并不依赖于IL-27,因而不会被Th17细胞所抑制。这些发现提示BBI可能是治疗多发性硬化等自身免疫病的潜在药物。 Figure ...
Tr1 cells, or type 1 regulatory T cells, are a subset of CD4+ T cells that play a crucial role in immune regulation and tolerance. Here’s an overview of the action of Tr1 cells: Immune Suppression: Tr1 cells possess immunosuppressive properties and help regulate immune responses. They secre...
MSCs induce production of Tr1 cells, decrease of Th17 cells, and mitigate aneurysm development in the elastase AAA mouse model. When treated with MSCs, AAA patients show increases in the number of Tr1 cells along with a concurrent Th17 decrease. These cell effects are dose-dependent, and ...
Inducement of silver-specific T cell tolerance using the soluble form of each determinant; Cause of the rapid effect of soluble peptide therapy; Two types of T cells that participate in the induction of active tolerance.关键词: Animals Rats, Inbred Lew Rats Lymph Nodes Spleen T-Lymphocytes ...
Acute viral infection with lymphocytic choriomeningitis virus (LCMV) had no impact on Tr1 cell number and function, neither on the Tr1 cells infused nor on the ones induced, and that was reflected in the robust maintenance of the graft. Moreover, Tr1 cell immunotherapy had no detrimental effect...
Nicholas Koylass2, Song-Guo Zheng1,3 & Avery August2 Type 1 regulatory T (Tr1) cells differentiate in response to signals engaging the T cell receptor (TCR), express high levels of the immunosuppressive cytokine IL-10, but not Foxp3, and can suppress inflammation and promote immune tolerance...