在一项对小鼠进行的新研究中,他们指出免疫细胞的一个亚群——1型调节性T细胞(type 1 regulatory T cell, Tr1细胞),在防止免疫系统过度反应方面发挥了正常作用,但却在无意中抑制了免疫疗法的抗癌能力。相关研究结果发表在2024年8月1日的Nature期刊上,论文标题为“Neoantigen-specific cytotoxic Tr1 CD4 T cells suppre...
Many cell subsets with regulatory function have been described, including natural CD4+CD25+Foxp3+ T cells and acquired regulatory T cells such as regulatory type I cells (Tr1) or Th3 cells. They are generated from different precursors and have different mechanisms of action. Tr1 cells are ...
参考资料: Drug Bypasses Suppressive Immune Cells to Unleash Immunotherapy Neoantigen-specific Cytotoxic Tr1 CD4 T Cells Suppress Cancer Immunotherapy When Will Patients See Personalized Cancer Vaccines? Exploring Treatment Options in Cancer: Tumor Treatment Strategies Robinson and Schwarz Recognized by ASTRO ...
Type 1 regulatory T cells (Tr1 cells) are an important subset of CD4+ T cells that prevent excessive inflammatory responses and maintain immune tolerance. The anti-inflammatory role of Tr1 cells is mediated in part by their production of interleukin 10 (IL-10), which dampens the function of...
2024年8月1日,国际知名学术期刊《Nature》发表了一项令人瞩目的研究成果,题为“Neoantigen-specific cytotoxic Tr1 CD4 T cells suppress cancer immunotherapy”。该研究由华盛顿大学医学院的Robert D. Schreiber博士团队主导,揭示了免疫系统中一种名为Tr1的CD4+ T细胞在癌症免疫疗法中的意外抑制作用,并探索了克服这一障...
Interestingly, the presence of Tr1 cells in vivo correlated with long term allograft tolerance without the need of immunosuppressive treatment. Since then, Tr1 cells were further characterized and efficient...doi:10.1097/00007890-201211271-00105Petrelli, A....
Acute viral infection with lymphocytic choriomeningitis virus (LCMV) had no impact on Tr1 cell number and function, neither on the Tr1 cells infused nor on the ones induced, and that was reflected in the robust maintenance of the graft. Moreover, Tr1 cell immunotherapy had no detrimental effect...
Abdolmohamad Rostami教授发现BBI可以通过IFN-g/STAT1途径来促进Tr1细胞的产生,进而可以有效控制自身免疫炎症。特别是这一过程并不依赖于IL-27,因而不会被Th17细胞所抑制。这些发现提示BBI可能是治疗多发性硬化等自身免疫病的潜在药物。 Figure ...
Nicholas Koylass2, Song-Guo Zheng1,3 & Avery August2 Type 1 regulatory T (Tr1) cells differentiate in response to signals engaging the T cell receptor (TCR), express high levels of the immunosuppressive cytokine IL-10, but not Foxp3, and can suppress inflammation and promote immune tolerance...
We found that murine T1 cells expressed functional IL-10Rα. T1 cells with impaired IL-10 receptor signaling lost their regulatory activity in vivo. T1 cells required IL-10 receptor signaling to activate p38 MAPK, thereby sustaining IL-10 production, which ultimately mediated their suppressive ...