TR1 Cellsdoi:10.1007/3-540-27806-0_1492Suppressor CellsSpringer Berlin HeidelbergEncyclopedic Reference of Immunotoxicology
在一项对小鼠进行的新研究中,他们指出免疫细胞的一个亚群——1型调节性T细胞(type 1 regulatory T cell, Tr1细胞),在防止免疫系统过度反应方面发挥了正常作用,但却在无意中抑制了免疫疗法的抗癌能力。相关研究结果发表在2024年8月1日的Nature期刊上,论文标题为“Neoantigen-specific cytotoxic Tr1 CD4 T cells suppre...
在一项对小鼠进行的新研究中,他们指出免疫细胞的一个亚群——1型调节性T细胞(type 1 regulatory T cell, Tr1细胞),在防止免疫系统过度反应方面发挥了正常作用,但却在无意中抑制了免疫疗法的抗癌能力。相关研究结果发表在2024年8月1日的Nature期刊上,论文标题为“Neoantigen-specific cytotoxic Tr1 CD4 T cells suppre...
相关研究结果发表在2024年8月1日的Nature期刊上,论文标题为“Neoantigen-specific cytotoxic Tr1 CD4 T cells suppress cancer immunotherapy”。O网页链接 û收藏 转发 评论 ñ2 评论 o p 同时转发到我的微博 按热度 按时间 正在加载,请稍候... 上海春谷生物医药科技有限公司 ü 审核时间 2024-...
[关键词] I I 型调节 T T 细胞 ; IL-10 ; 树突状细胞 ;移植物抗宿主病移植物抗宿主病[中图分类号] R392. 11 R392. 11 [文献标识码] A A调节性 T T 细胞( ( regulatory T cells , Treg) )在体内担负着重要的免疫调节作用在体内担负着重要的免疫调节作用 ,是诱导针对自身以及外来抗原产生外周...
IL-10+Tr1 cells, which do not express stable Foxp3 like conventional Treg cells, are associated with various diseases, but little is known about how their differentiation and function are regulated. Here the authors show that ITK is a central TCR signalling effector of the differentiation and ...
In addition, Tr1 cells induced by iDCs do not require the presence of CD4+CD25+ Tr cells for their generation, nor do they express high constitutive levels of CD25 or the transcription factor FoxP3. Thus, iDCs can drive the differentiation of Tr1 cells and can be used to generate large ...
Interestingly, the presence of Tr1 cells in vivo correlated with long term allograft tolerance without the need of immunosuppressive treatment. Since then, Tr1 cells were further characterized and efficient...doi:10.1097/00007890-201211271-00105Petrelli, A....
Acute viral infection with lymphocytic choriomeningitis virus (LCMV) had no impact on Tr1 cell number and function, neither on the Tr1 cells infused nor on the ones induced, and that was reflected in the robust maintenance of the graft. Moreover, Tr1 cell immunotherapy had no detrimental effect...
Inducement of silver-specific T cell tolerance using the soluble form of each determinant; Cause of the rapid effect of soluble peptide therapy; Two types of T cells that participate in the induction of active tolerance. 展开 关键词: Animals Rats, Inbred Lew Rats Lymph Nodes Spleen T-...