synthesis, cytotoxic compounds, lactones, tetrahydrofuranic annonaceous acetogenins, drugs, furans, AnnonaceaeAn eleven-step reaction sequence starting from enantiomerically pure ()-muricatacin (6) afforded the key intermediate 12, which was then converted to (15S, 16R, 19S, 20R, 34S)-diepo...
Total synthesis of (±)-prostagladin D 1 : use of triethylsilyl protecting groups. Terance W. Hart,David A. Metcalfe,Feodor Scheinmann. J. Chem. ... TW Hart,DA Metcalfe,F Scheinmann - 《Journal of the Chemical Society》 被引量: 24发表: 1979年 Prostaglandin-mediated inhibition of noradr...
Anthracyclines such as doxorubicin are effective anticancer drugs composed of a tetracyclic polyketide aglycone and one or more deoxysugar moieties, which ... E Kim,MC Song,MS Kim,... - 《Acs Combinatorial Science》 被引量: 5发表: 2017年 Amrubicin synthesis method The method of the present in...
Total synthesis of (+)-vinblastine: control of the stereochemistry at C18'. 来自 掌桥科研 喜欢 0 阅读量: 56 作者:S Yokoshima,H Tokuyama,T Fukuyama 摘要: Vinblastine has been widely known as a prominent agent in cancer chemotherapy, and in order to search for more potent drugs, various ...
Gram‐Scale Synthesis of Chiral Cyclopropane‐Containing Drugs and Drug Precursors with Engineered Myoglobin Catalysts Featuring Complementary Stereoselect... Bajaj, Priyanka,Sreenilayam, Gope...,Tyagi, Vikas,... - 《Angewandte Chemie》 - 2016 - 被引...
- 《Marine Drugs》 被引量: 16发表: 2004年 Total Synthesis of (+)-Amphidinolide A. Structure Elucidation and Completion of the Synthesis The structure elucidation of (+)-amphidinolide A, a cytotoxic macrolide, has been accomplished by employing a combination of NMR chemical shift analysis an....
摘要: The first enantioselective total synthesis of (+)-stachyflin, a potentialanti-influenza A virus agent, was achieved; the method features a BF3·Et2O-induced domino epoxide-opening/rearrangement/cyclization reaction to stereoselectively form the requisite pentacyclic ring system in one step....
Total synthesis of (+)-phorboxazole A, a potent cytostatic agent from the spongePhorbassp. Synthetic strategyThe structure of phorboxazole A (1) is based on a 21-membered macrolactone core, which accommodates atrans-fused oxane, twocis-... G Pattenden - 《Organic & Biomolecular Chemistry》...
Nature continues to serve as an invaluable source for the development of pharmaceutical drugs1, agrochemical agents2, and biomedical probes3. In this context, efficient total synthesis of these bioactive natural products is of crucial importance4. With significant advances in synthetic methodologies and...
The total synthesis of (+)-α-CBT ( 16 ) was effected from the achiral 17-membered ketone 3 by a sequence featuring asymmetric reduction, diastereoselective [2,3] Wittig ring contraction and hydroxyl directed epoxidation as stereochemically important steps. DOI: 10.1016/S0040-4039(01)80357-9 ...