Synthesis of new hydrophilic γ-substituted poly-ε-caprolactones ring-opening polymerization (ROP) ; lactone P. Lecomte,V. D'Aloia,M. Mazza,... - 《Tetrahedron Letters》 被引量: 6发表: 2000年 Synthesis and Evaluation of a Star Amphiphilic Block Copolymer from Poly(ε-caprolactone) and Poly...
would find extensive application in the discovery of transformational medicines. Significant synthesis challenges arise from the fact that drug molecules typically contain amines and N-heterocycles, as well as unprotected polar groups. There is also a need for new reactions that enable non-traditional ...
Aim To synthesize carbasalate magnesium,a new medicine which may play a role in the treatment of the cardiovascular disease.Method Carbasalate magnesium was synthsized from Asprin(acetyl salicylic acid),Mg(OH) 2·4MgCO 3·6H 2O and urea by a two step preparing method.The optimization of the...
Pyrazinamide (PZA) is one of the most important drugs for the treatment of Mycobacterium tuberculosis infection. However, the increasing frequency of PZA-r... KW Lee,JM Lee,KS Jung - 《Journal of Korean Medical Science》 被引量: 152发表: 2001年 Characterization of new mutations in pyrazinamide...
release, differentiating this process from a more typical amorphous sol-gel approach32. Other drugs exist with self-assembling and self-aggregating properties which could now be considered for mesoscale co-assembly to design a range of new drug encapsulation vehicles through bottom-up synthesis70,71,...
oedemic properties of these drugs are revealed, suggesting that prostanoids may potentiate some of the NSAIDs which do not inhibit prostanoid synthesisper ... MW Whitehouse,B Vernon-Roberts - 《Inflammopharmacology》 被引量: 10发表: 1991年 Diazine derivatives This invention concerns compounds of...
There is an urgent need for the development of new drugs for the treatment of tropical parasitic diseases such as Chagas' disease and leishmaniasis. One po... SB Cammerer,C Jimenez,S Jones,... - 《Antimicrobial Agents & Chemotherapy》 被引量: 38发表: 2007年 ...
Newman DJ, Cragg GM, Snader KM (2003) Natural products as sources of new drugs over the period 1981–2002. J Nat Prod 66: 1022–1037 PubMed CAS Google Scholar Tanaka H, Kuroda A, Marusawa H, Hatanaka H, Kino T, Goto T, Hashimoto M, Taga T (1987) Structure of FK506, a novel...
A simple highly adjustable and effective synthesis of aryl imidazole ligand HL namely (2-(1-butyl-4,5-diphenyl-1H-imidazole-2-yl) (4-bromophenol) was discussed where it was prepared by cyclo condensation of 5-bromo-2-hydroxybenzaldehyde, benzil and butan-1-amine. Three new Cr(III), Fe(II...
摘要: A new type of tropolone and tropone derivatives condensing fluorene moiety were prepared from 8, 9-dihydro-8-oxo-13bH-tribenzo [a, cd, h] azulene by oxidation with selenium dioxide and by dehydrogenation with DDQ, respectively.