Chemical modification of DNA is a common strategy to improve the properties of oligonucleotides, particularly for therapeutics and nanotechnology. Existing synthetic methods essentially rely on phosphoramidite chemistry or the polymerization of nucleosid
A methyl group, on the other hand, has the capacity to fill a hydrophobic pocket of the protein and/or to induce a favourable conformational change of the molecule to modulate its biological activity, selectivity, solubility, metabolism and pharmacokinetic/pharmacodynamic properties [13]. The ...
The development of automated and high-throughput synthesis in droplets has greatly facilitated combinatorial synthesis, small-molecule drug discovery, and biomacromolecule evolution53,54,55,56,57,58. While some studies have utilized microplates to investigate automatic synthesis with open characterization59,...
superior drug loadings, and activated discharge profile. These productions, known as hybrid inorganic NPs, often have an inorganic core and an organic shell [25,26,27]. The use of NPs, generally between 0.2 and 100 nm in size, has proven effective as a new antibacterial strategy. Gold (Au...
DNA synthesis is a complicated process involving anabolic processes to create the purine and pyrimidine nucleotide triphosphates required for replication, unwinding of the template DNA to provide access to the replication machinery, and the high fidelity process of creating complementary strands. ...
Gold nanocages are hollow gold nanoparticles with a cage-like structure. Moreover, they have a high specific surface area, excellent surface modifiability, and a high drug-loading rate, thus making them ideal for drug delivery [49, 50]. The use of different concentrations of gold seed solution...
To facilitate antiviral drug discovery, we developed an infectious cDNA clone of an epidemic strain of EV71 and a stable eGFP reporter EV71. The reporter virus was generated by engineering the eGFP gene between the 5′ untranslated region and VP4 ...
Hard templating involves the use of pre-synthesized mesoporous solids for nanocasting or colloidal nanocrystals as sacrificial templates. The stability of the hard templates makes it suitable for preparing functional mesoporous materials with a variety of compositions. However, this method is costly, time...
Fan et al. redesigned the inner surface of ferritin drug carrier (ins-FDC) nanocarrier as a drug delivery platform and used the urea-thermal incubation loading method to maximize the loading capacity of hydrophilic and hydrophobic drugs at the same time. The result shows that the dual-drug ...
molecule. After tuning the model’s hyperparameters using distinct training and validation sets, an MLP model was trained on all of the available data with a fixed number of epochs. This model was used for all subsequent analyses using synthetic targets selected from ZINC, MOSES, and FDA-...