hydrazine functionalities, amines, boronate esters/acids, aldehydes, and sulfonate acid/esters, and acyl (acid) halides used in the synthesis of pharmaceutical drug substances. Special focus is placed on stabil
Since p-xylene is mainly used as a precursor for terephthalic acid, the initial reduction of the side chains followed by the later oxidation seems rather wasteful; however, the DA reaction either does not work or works very poorly on oxygenated variants of 2,5-dimethylfuran26. Besides, the ...
The development of automated and high-throughput synthesis in droplets has greatly facilitated combinatorial synthesis, small-molecule drug discovery, and biomacromolecule evolution53,54,55,56,57,58. While some studies have utilized microplates to investigate automatic synthesis with open characterization59,...
The effective and potent activity of Favipiravir against RNA influenza viruses makes it a promising drug that could be used for specifically untreatable RNA viral infections. Recently, Favipiravir showed promising in-vitro results against SARCoV-2 in early clinical studies [19]. The fourth drug ...
2. Role of gold in total synthesis of indole alkaloids 3. Role of palladium in total synthesis of indole alkaloids 4. Role of copper in total synthesis of indole alkaloids 5. Role of nickel in total synthesis of indole alkaloids 6. Role of iridium in synthesis and total synthesis of indole...
a preventative measure. But, in line with the current trend of human bacteria becoming more antibiotic-resistant, drug resistance has also grown in people with gum disease over the past few years. Antibiotics don't work as well on these germs because of the particular environment in the gum ...
Water, which is an indispensable part of life, is under the negative effects of industrialization and modernization (Gul et al.2022). There is a great increase in the environmental pollution problem due to the mixing of various pollutants into water due to increases in industrial production. The...
This review focuses on the recent advances in the synthesis of graphene quantum dots (GQDs) and their applications in drug delivery. To give a brief understanding about the preparation of GQDs, recent advances in methods of GQDs synthesis are first presented. Afterwards, various drug delivery-relea...
Chemical modification of DNA is a common strategy to improve the properties of oligonucleotides, particularly for therapeutics and nanotechnology. Existing synthetic methods essentially rely on phosphoramidite chemistry or the polymerization of nucleosid
. The methods utilized included molecular docking, density functional theory (DFT) calculations using the B3LYP/6-31++G(d,p) basis set in the gas phase, molecular dynamic (MD) simulation, as well as the evaluation of drug-likeness scores. The pharmacokinetic and drug-likeness properties of...