Such associations are driven by tissue-specific gene expressions, which share genetic basis with the total genetic contributions. TGCA can provide a genome-wide atlas for the overall genetic contributions in each particular domain of human complex traits. Quantifying the effects of individual loci on ...
GIP, also known as a gastric inhibitory polypeptide, or glucose-dependent insulinotropic polypeptide is encoded by the gene mapped to human chromosome 17q12-q21. It is synthesized in and secreted from K cells in the intestinal epithelium. GIP secretion from the gastrointestinal tract plays a major...
X-linked retinoschisis (XLRS) is the most common cause of juvenile macular degeneration in males, resulting in vision loss early in life. The gene involved... JTD Dunnen,T Kraayenbrink,MV Schooneveld,... - 《Human Molecular Genetics》 被引量: 301发表: 1998年 Collagen accumulation in mu...
Relationship between the Concentrations of Glycolytic Intermediates and Expression of the L-Type Pyruvate Kinase Gene in Cultured Hepatocytes Previous studies have suggested that some glycolytic intermediates are involved in the regulation of L-type pyruvate kinase gene expression by carbohydrate... Rujun,...
Gene expression profiling of breast cancer cell lines in response to soy isoflavones using a pangenomic microarray approach. Although the rate of breast cancer differs between women in Asian and Western countries, molecular genetics/genomics basis of this epidemiological observat... S Satih,N Chalabi...
aHeatmap of mean log10intensities of identified TRIM proteins in healthy control (HC) and dermatomyositis (DM). Gene ontology processes significantly enriched inbDM, andcHC.dBinary colour-coding of presence/absence of the autoantibody protein targets that were enriched in at least six out of eight...
IL13, IL4, IL4RA, FCER1B and ADRB2 are susceptible genes of asthma and atopy. Our previous study has found gene–gene interactions on asthma between these genes in Chinese Han children. Whether the interactions begin in fetal stage, and whether these gen
Optimization involved modulating the two mitochondrial systems and disrupting of unwanted side reactions associated with ATF2, GCY1, and YPR1 gene products. Hydrocortisone was the major steroid produced. This work demonstrates the feasibility of transfering a complex biosynthetic pathway from higher ...
aDawkins, in his landmark book on evolutionary biology The Selfish Gene, coined the term “meme” to connote a unit of culture that can evolve over time, analogous to a gene in biology. Dawkins,在他的地标书在进化生物学Selfish基因,在生物形成术语“meme”隐含可能随着时间的过去演变文化的...
Total synthesis of a human leukocyte interferon gene. A 514-base pair fragment of double-stranded DNA coding for human interferon-alpha 1 (166 amino acid residues), and containing initiation and termination si... M D,Edge,A R,... - 《Nature》 被引量: 201发表: 1981年 Consensus human leu...