miRNAsmiRNA-122lung transplantationToll-like receptor signaling pathwayObjective:MiRNAs have been recently implicated in the pathogenesis of ischemia-reperfusion(IR)injury.This study aimed to investigate the miRNA expression profiles,in the early stages after lung transplantation(LT)and to study the involvem...
Toll-like receptors (TLRs) play a pivotal role in innate immune responses against microbes through the recognition of pathogen-associated molecular patterns.12TLR9 senses unmethylated CpG DNA from bacteria and viruses to initiate type I interferon (IFN) and proinflammatory cytokine production by immune ...
Toll-like receptor signaling pathways. Frontiers in immunology 5, 461, doi: 10.3389/fimmu.2014.00461 (2014). 6. Satake, H. & Sekiguchi, T. Toll-like receptors of deuterostome invertebrates. Frontiers in immunology 3, 34, doi: 10.3389/ fimmu.2012.00034 (2012). 7. Palti, Y. Toll-like ...
MSCs express various genes in the Toll-like receptor pathway, recruiting cells to sites of injury by activating both the innate and adaptive immune system. TLR4 and TLR3 and their ligands have the capability to induce nuclear factor-κβ activity as well as the production of IL-6, IL-8, ...
KEGG pathway analysis presented abundance of downregulated genes in several cascades, comprising the NOD-like receptor signaling pathway, mitogen-activated protein kinase (MAPK) signaling pathway, and TLR signaling pathway (Supplementary Figure S1). In the oridonin-treated group d, 278 genes with fold...
RNA-Seq results indicated that the Toll-like receptor signaling pathway is one of the main pathways regulated by TPG-1. Moreover, there is much evidence that Toll-like receptor 4 (TLR4) is essential for activation of NF-κB and MAPK signaling (10, 22, 2324). Thus, next we investigated ...
Transcriptome-wide identification and characterization of Toll pathway genes in Riptortus pedestris (Hemiptera: Alydidae) 2025, Developmental and Comparative Immunology Macrophage-like Blood Cells Are Involved in Inter-Tissue Communication to Activate JAK/STAT Signaling, Inducing Antitumor Turandot Proteins in...
Signaling pathwayToll-like receptor (TLR)Interferon regulatory factor (IRF)Schizothorax prenatal (S. prencmd), an important species of economical fish in Southwest China, is susceptible to Aeromonas hydrophila (Ah). To understand the immune response to Ah, the transcriptome profiling of spleen of S...
NAD+can be catabolized by enzymes involved in cellular signaling processes through cleaving the diphosphate bridge joining the two nucleotides or theβ-N-glycosidic bond linking ADP-ribose (ADPR) and NAM33,34. Recent studies have shown that Toll/interleukin-1 receptor (TIR) domain-containing prote...
(NF-κB; Fig.3j), suggesting an immunomodulatory mechanism of simultaneous activation of diversified targets and the initiation of immune signaling pathways (including NF-κB). We next performed KEGG (Kyoto encyclopedia of genes and genomes) pathway analysis to investigate the functions of these ...