toll-like receptor signaling pathway是一种重要的免疫系统信号传导途径,它在宿主抵御感染和炎症调节中起着关键作用。本文将逐步介绍toll-like receptor(TLR)信号传导途径,并探讨其在免疫应答中的意义。 第一部分:导言(200-300字) 免疫系统是人体的防御机制,负责识别和清除有害的病原体。免疫应答依赖于免疫细胞和分子...
Role of hepatic stellate cell(HSC)-derived cytokines in hepatic inflammation and immunity,Cytokine,Volume 124, December 2019 Adamiak M, Abdelbaset-Ismail A, Kucia M, et al. Toll-like receptor signalingdeficient mice are easy mobilizers: evidence that TLR signaling prevents mobilization of hematopoie...
5. Tsokos, G.C., et al., New insights into the immunopathogenesis of systemic lupus erythematosus.Nat Rev Rheumatol, 2016. 12(12): p. 716-730. 6. Blasius, A.L., et al., Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are r...
(2014). "Toll-like receptor signaling pathways." *Frontiers in Immunology. Liu X, Zhang Z. (2011). "Toll-like receptors, associated biological roles, and signaling networks in non-mammals." *Frontiers in Immunology. Takeda K, Akira S. (2005). "Toll-like receptors in innate immunity." *...
15.Satoh T,Akira S.Toll-like receptor signaling and its inducible proteins[J].Microbiol Spectr,2016,4(6):2016Dec;4(6).DOI:10.1128/microbiolspec.MCHD-0040-2016. 16.宋学萍,梁娟,王颖娥,等.Toll样受体4与肾纤维化的...
近日,来自暨南大学的研究者们在Acta Pharmacologica Sinica杂志上发表了题为“Regulation of toll-like receptor (TLR) signaling pathways in atherosclerosis: from mechanisms to targeted therapeutics”的综述性文章,该研究总结了动脉粥样硬化中Toll样受体(TLR)信号通路的调控:从机制到靶向治疗。
Toll-like receptors signaling: A complex network for NF-κB activation in B-cell lymphoid malignancies. Semin Cancer Biol. 2016;39:15-25.Ntoufa S, Vilia MG, Stamatopoulos K, Ghia P and Muzio M: Toll‑like receptors signaling: A complex network for NF‑κB acti- vation in B‑cell ...
signalingreceptortlrsliketlrpathways VIEWPOINTToll-LikeReceptorSignalingPathwaysGregoryM.BartonandRuslanMedzhitov*MembersoftheToll-likereceptor(TLR)familyrecognizeconservedmicrobialstruc-tures,suchasbacteriallipopolysaccharideandviraldouble-strandedRNA,andactivatesignalingpathwaysthatresultinimmuneresponsesagainstmicrobialinfectio...
Toll-like receptors (TLRs) have an extracellular region, which contains leucine-rich repeat motifs, and a cytoplasmic tail, which has a Toll/interleukin-1(IL-1) receptor (TIR) domain. Different TLRs recognize different surface and intracellular components of microorganisms. ...