Toll样受体(Toll-like receptor,TLR)是一类典型的模式识别受体,TLR信号通路介导的先天性免疫异常与肠道炎症性病变关系密切,特别是肠上皮细胞和固有层免疫细胞表达的TLR4,是识别并应答革兰阴性菌上的脂多糖的最主要受体,其介导的TLR4信号通路...
Toll样受体在肾脏炎症反应中的信号通路 热度: 炎症反应Toll信号传导通路 [主题词]炎症;信号传递;基因 [中分类号]R364.5[文献标识码]A [文章编号]1000-4718(2000)06-0567-06 Tollreceptorsignalingpathwayininflammation WANGBo-yao,HUANGNing,WUQi (ResearchUnitofInfection&Immunity,DepartmentofPathophysiology,West ...
signaling pathwaytoll like receptorToll like receptor (TLR) signaling is involved in activating innate and adaptive immune responses and plays a critical role in inflammation‐induced diseases such as colorectal cancer (CRC). Dysregulation of this signaling pathway can result in disturbance of epithelial...
Toll样受体(Toll-like receptor,TLR)是一类天然免疫受体,可识别损伤相关分子模式并介导机体炎症反应,其中TLR4为炎症反应通路的启动蛋白。在多种疾病、损伤的病理机制研究中,Toll样受体连同下游NF-κB通路均是研究重点。 除了参与病原微生物触发的炎症反...
亦有报道细菌脂蛋白能介导转染了Tlr-2编码基因的293细胞的凋亡,提示Tlrs可能在炎症反应的负相调节机制中发挥作用[16]。 三、感染性炎症反应的Toll信号转导通路[12, 17, 18] Fig 4 Toll and Toll-like receptor-mediated intracellular signaling (From Hoffman JA, et al. Science, 1999, 284:1313 with a ...
1、炎症反应Toll信号传导通路主题词炎症; 信号传递; 基因中分类号R364.5文献标识码A文章编号1000-4718(2000)06-0567-06 Toll receptor signaling pathway in inflammation WANG Bo-yao, HUANG Ning, WU Qi(Research Unit of Infection & Immunity, Department of Pathophysiology, West China University of Medical ...
调 控TLR2和TLR4信号通路,有望给予牙周炎、炎症性肠炎、心血管疾病及和自身免疫性疾病等更有效和更安全的临 床治疗。 [关键词】Toll样受体 ;信号通路 ;转导抑制;炎症治疗 【中图分类号】Q51 文【献标志码】A Idoi1 10.7518/gjkq.2014.03.014 RoleandsignificanceofToll—likereceptors2and4signalingpathwayin...
Interactive toll-like receptor signaling pathway depicting the activation of innate and acquired immunity, along with an inflammatory response and the up-regulation of cytokines. Targets lead to related information & Tocris products.
进一步的研究探讨。方法:Toll—likereceptor2(TLR2)不仅是激活机体自身免疫防御和炎症反应的重要受体,而且广泛参与多种 细胞功能,包括细胞凋亡。我们使用体外培养的HEK293和高表达TLR2的HEK2932种细胞,以及体外培养小鼠皮层原代神 经元细胞,研究经过吗啡处理后细胞存活率和凋亡的变化,以探讨TLR2信号通路在吗啡诱导的细胞...
Previous studies have shown that genetic variation in the Toll-like receptor (TLR) signaling pathway is associated with PCa incidence, but any role in progression and mortality is unclear. Among 1,252 PCa cases from the Cancer Prostate in Sweden study, we conducted time-to-event analyses of ...