. Furthermore, these 44 DEGs were enriched in other interleukin signaling pathways, such as JAK-STAT, IL-12, IL-17, IL-23, TNF, chemokines (GPCR ligand binding) and PRRs, including RIG-I-like receptor and NOD signaling. Multistudy factor analysis of eligible33datasets (WBCs: Dix et al....
(1 mg/ml) - +- + 0 RG-II (1 mg/ml) - + - + Figure 5 Rhamnogalacturonan II (RG-II)-mediated activation of Toll-like receptor 4 (TLR4) stimulates the MyD88 (myeloid differentiation primary response gene 88) and TRIF (TIR-domain-containing adapter-inducing interferon-b) signaling ...
Diabetologia (2008) 51:336–346 DOI 10.1007/s00125-007-0861-3 ARTICLE Inhibition or deletion of the lipopolysaccharide receptor Toll-like receptor-4 confers partial protection against lipid-induced insulin resistance in rodent skeletal muscle M. S. Radin & S. Sinha & B. A. Bhatt & N. Dedou...
TLR4 triggers NFκB signaling through the ubiquitin ligase TRAF6 (tumor necrosis factor receptor-associated factor 6). TRAF6 activity can be impeded by deubiquitinating enzymes like ubiquitin-specific protease 20 (USP20), which can reverse TRAF6 autoubiquitination, and by association with the ...
Regions of mouse CD14 required for Toll-like receptor 2 (TLR2)- and TLR4-mediated activation of NF-κB were studied in transiently transfected 293 cells. Wild-type CD14 enhanced lipopolysaccharide (LPS)-induced NF-κB-dependent reporter activity in cells expressing TLR4/MD-2, and deletion of ...
L. Toll-like receptor 9 signaling acts on multiple elements of the germinal center to enhance antibody responses. Proc. Natl Acad. Sci. USA 111, E3224–E3233 (2014). 31. Lau, C. M. et al. RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like ...
Natural killer (NK) cells are the main mediator of the cytotoxic response in innate immunity and may be involved in resistance to HIV-1 infection in exposed seronegative (ESN) individuals. Toll-like receptor (TLR) signalling is crucial for NK cell activation. Here, we investigated the polyfunct...
Furthermore, defective lymphopoiesis correlated strongly with failure of hematopoietic progenitors to form close contact with stromal cell niche and was not the result of the defect in the assembly of antigen receptor or interleukin-7 signaling. These findings define gp96 as the only known molecular ...