Toll-like receptor 4 signaling pathway in sensory neurons mediates remifentanil-induced postoperative hyperalgesia via transient receptor potential ankyrin 1doi:10.1177/17448069231158290SENSORY neuronsTOLL-like receptorsDORSAL root gangliaCELLULAR signal transductionHYPERALGESIA...
(MAPKs)extracellularsignal–regulatedkinase(ERK),p38,c-JunN-terminalkinaseJNK)[seeTLRpathwayproximaleventssignalingpathwaydepend,teractionsbetweenmodularsignalingdomains.OneToll/interleukin(IL)–1receptor(TIR)domain,whichcytosolicregionallTLRs,IL-1receptorfamily.TIRdomaingovernshomodimerizationbetweenTLRsassociation...
dissectionofthepathwaystheyactivatehas becomeanimportantemergingresearchfocus.TLRsandtheirpathwaysarenumer- ous;Science’sSignalTransductionKnowledgeEnvironment’sTLRConnectionsMap providesanimmediate,clearoverviewoftheknowncomponentsandrelationsof thiscomplexsystem. TheTLRfamilyisafamilyofreceptorsin- volvedinmicrobial...
For additional details, refer tothe Science’s Signal Transduction KnowledgeEnvironment Connections Map of the Toll-likereceptor pathway (2).B U I L D I N G S I G N A L I N G C O N N E C T I O N S6 JUNE 2003VOL 300SCIENCEwww.sciencemag.org1524SPECIAL SECTION ...
018AToll-Like Receptor Signaling Pathway EpiTect ChIP qPCR ArrayMouseHistone ModificationsGM-018A The Human Toll-Like Receptor Signaling Pathway EpiTect ChIP qPCR Array profiles the histone modification status or “histone code” of 84 genes central to TLR-mediated signal transduction and innate ...
After microbial detection, these receptors activate inflammatory signal transduction pathways that involve IκB kinases, mitogen-activated protein kinases, ubiquitin ligases and other adaptor proteins. The mechanisms that connect the proteins in the TLR pathways are poorly defined. To delineate TLR pathway...
TRAM is involved specifically in the TLR4-mediated, MyD88-independent pathway, whereas TIRAP mediates the TLR2- and TLR4-mediated, MyD88-dependent pathway. The TLR-signalling pathways are negatively regulated by TLR-inducible molecules — such as IRAK-M (IL-1-receptor (IL-1R)-associated kinase...
Toll-like Receptor Signaling Pathway Variants and Prostate Cancer Mortality An understanding of factors associated with prostate cancer (PCa) mortality is increasingly important given the biological heterogeneity of disease. Previo... JR Stark,F Wiklund,H Gronberg,... - 《Cancer Epidemiology Biomarkers ...
To explore the change of TLR-4 signal pathoway during hypoxia–reoxygenation (H-R) of cardiac microvascular endothelial cells (CMECs) injury. Methods The CMECs were isolated from the hearts of adult rats. The obtained CMECs were exposed to hypoxia (940 ml/l N2, 50 ml/l CO2 and 10 ml...
(LPS) of Gram-negative bacteria and stimulates the synthesis and release of inflammatory cytokines through activation of the NF-κB signaling pathway,which ultimately results in inflammatory responses that involve multiple organs.Animal and clinical studies have shown that the TLR4 signal pathway plays ...