A transient state of hyporesponsiveness to subsequent stimulation with lipopolysaccharide (LPS), which is induced by the administration of Toll-like receptor ligandsin vivoandin vitro. About this article Cite this article Akira, S., Takeda, K. Toll-like receptor signalling.Nat Rev Immunol4, 499–...
van Maren, W.W., et al., Toll-like receptor signalling on Tregs: to suppress or not to suppress? Immunology, 2008. 124(4): p. 445-52.Van Maren WW,Jacobs JF,de Vries IJ,et al.Toll-likereceptor signalling on Tregs:to suppress or not to supp-ress?.Immunology. 2008...
TASL is an adaptor molecule bridging Toll-like receptor signalling and transcription activation by IRF5. Here the authors show that TASL deficiency impacts TLR7/9 responses, and that a TASL paralogue, Gm6377/TASL2, also contributes to IRF5 activation, as dual TASL/TASL2 deficiency dampens both...
As alluded to above, TLR signaling pathways are quite complex. Following recognition of a ligand by a specific TLR, the adaptor protein TIRAP/MyD88, which interacts with all of the TLRs except TLR3, initiates intracellular signaling cascades leading to downstream activation of IL-1 receptor-assoc...
Toll-like receptor signalling. One of the mechanisms by which the innate immune system senses the invasion of pathogenic microorganisms is through the Toll-like receptors (TLRs), which r... S Akira,K Takeda - 《Nature Reviews Immunology》 被引量: 1.3万发表: 0年 Toll-like Receptor Signaling ...
Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4. Toll-like receptors (TLRs), which recognize pathogen-associated molecular patterns, and members of the pro-inflammatory interleukin-1 receptor (IL-1R) fami... N Suzuki,S Suzuki,GS Duncan,... - 《Natu...
The present invention relates to toll-like receptor 3 (TLR3) and its\nsignalling\nassociated molecule TRIF. More specifically, the present invention relates to\nscreening methods for the identification of TLR3 and TRIF antagonists and\nmethods\nfor treating and/or preventing excessive host ...
Toll‐like receptor signalling has inverted U‐shaped response over time with the Western environmentenvironment and hygiene hypothesisIgEinnate immunitydoi:10.1111/all.14277Jing GuoYong SongAarti SaiganeshBelinda J. HalesAnthony BoscoPeter N. Le Souëf...
Takeda Toll-like receptor signalling Nat Rev Immunol, 4 (2004), pp. 499-511 CrossrefView in ScopusGoogle Scholar [36] T. Kawai, S. Akira TLR signaling Semin Immunol, 19 (2007), pp. 24-32 View PDFView articleGoogle Scholar [37] K.A. Fitzgerald, D.C. Rowe, B.J. Barnes, D.R....
It is now well appreciated that these regulatory T cells (Tregs) play a pivotal role in controlling immune function. Interestingly, recent studies revealed that TLR2 signalling affects Treg expansion and function. This review will focus on the presence and 展开 ...