toll-like receptor signaling pway toll-like receptor signaling pathway是一种重要的免疫系统信号传导途径,它在宿主抵御感染和炎症调节中起着关键作用。本文将逐步介绍toll-like receptor(TLR)信号传导途径,并探讨其在免疫应答中的意义。 第一部分:导言(200-300字) 免疫系统是人体的防御机制,负责识别和清除有害的病...
方法:Toll—likereceptor2(TLR2)不仅是激活机体自身免疫防御和炎症反应的重要受体,而且广泛参与多种细胞功能,包括细胞凋亡。我们使用体外培养的HEK293和高表达TLR2的HEK2932种细胞,以及体外培养小鼠皮层原代神经元细胞,研究经过吗啡处理后细胞存活率和凋亡的变化,以探讨TLR2信号通路在吗啡诱导的细胞凋亡中的作用。结果:...
图1 Toll样受体介导的信号通路Fig.1 Toll like receptors mediated signaling pathway.TLRs signaling pathways can be divided into MyD88-dependent and MyD88-independent pathways.Different from TLR5,TLR7,and TLR9,which can directly interact with MyD88,TLR2 and TLR4 require coordination of MyD88 and TIRA...
Fig. 1 Toll like receptors mediated signaling pathway. TLRs signaling pathways can be divided into MyD88-dependent and MyD88-independent pathways. Different from TLR5, TLR7, and TLR9, which can directly interact with MyD88, TLR2 and ...
Toll-like receptor 2 (TLR2) is a member of an evolutionarily conserved Toll-like receptor family that recognizes Grampositive bacterial lipoproteins. TLR2 engagement results in MyD88-dependent signaling events leading to NF-[kappa]B activation and subsequent produc...
signalingreceptortlrsliketlrpathways VIEWPOINTToll-LikeReceptorSignalingPathwaysGregoryM.BartonandRuslanMedzhitov*MembersoftheToll-likereceptor(TLR)familyrecognizeconservedmicrobialstruc-tures,suchasbacteriallipopolysaccharideandviraldouble-strandedRNA,andactivatesignalingpathwaysthatresultinimmuneresponsesagainstmicrobialinfectio...
内容提示: V I E W P O I N TToll-Like Receptor Signaling PathwaysGregory M. Barton and Ruslan Medzhitov*Members of the Toll-like receptor (TLR) family recognize conserved microbial struc-tures, such as bacterial lipopolysaccharide and viral double-stranded RNA, andactivate signaling pathways that...
et al. Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1,and activates two distinct transcription factors,NF-kappa B and IFN-βregulatory factor-3,in the Toll-like receptorsignaling(J). J Immunol, ...
Background: A growing body of evidence supports a role for Toll-like receptor 4 (TLR4), a primary receptor of the innate immune system, in atherosclerosis ... Katsargyris,Athanasios,Tsiodras,... - 《Cerebrovascular Diseases》 被引量: 2发表: 2010年 加载更多研究点推荐 Cerebrovascular diseases ...
Toll样受体(Toll-like receptors,TLRs)是天然免疫中最重要的模式识别受体(pattern recognition receptor,PRR)之一。Toll蛋白最早被发现参与调控果蝇(Drosophila melanogaster)早期胚胎背腹轴的发育【1】。Hashimoto等发现敲除果蝇Toll后,果蝇会因全身长满霉菌...