新生儿坏死性小肠结肠炎(necrotizing enterocolitis,NEC)发生机制尚不清楚,肠上皮细胞Toll样受体4(toll-like receptor 4,TLR4)介导的TLR4信号通路被认为是激活NEC炎症风暴的关键因素。本文围绕TLR4信号通路及其上、下游信号靶点抑制,以及部分关键...
Since the toll-like receptor 4 (TLR4) pathway, an important pathway involved in inflammation induction, has previously been associated with solid tumors, we hypothesized that it would be correlated with the pathophysiological characteristics of AML patients and could be considered as an anticancer ...
wereviewtherecentprogressofmoleculesinvolvedinTLR4signalingpathwayandtheirregulatorymechanisms.[Keywords]Toll-likereceptor4;Signalingpathway;Inflammatoryresponse;Immunoregulation0引言模式识别受体(pattern-recognitionreceptors,PRRs)是固有免疫中识别病原微生物表面的病原模式相关分子(pathogen-associatedmolecularpattern,PAMPs)并...
近些年来有研究发现Toll样受体4(toll like receptor 4,TLR4)与Nod样受体蛋白3(nod-like receptor family pyrin domain-containing protein 3,NLRP3)炎性小体作为细胞炎症因子可以通过启动天然免疫,刺激相应的信号通路途径产生细胞因子和...
应用siRNA技术敲除TLR8、MyD88和白介素-1受体相关激酶4 (Interleukin-1 receptor-associated kinase 4,IRAK4) 后,Treg的免疫抑制功能不再被Poly-G10逆转,该实验进一步表明TLR8对于Treg抑制功能的逆转直接依赖于上述效应分子。在T、B细胞都缺陷的Rag1-/-小鼠肿瘤模型中,转输TLR8配体刺激的Treg实验发现TLR8介导的...
Sulfated Cyclocarya paliurus polysaccharides exert immunomodulatory potential on macrophages via Toll-like receptor 4 mediated MAPK/NF-κB signaling pathways Yue Yua,b, Haibin Zhua,b, Mingyue Shena, Qiang Yua,b, Yi Chena, Shiru Moa,b, Jianhua Xiea,b,* ...
方法:检索截至2022年12月的PubMed、中国知网等文献数据库中的相关文献,中文检索词为“Toll样受体,成骨细胞,破骨细胞,间充质干细胞,巨噬细胞,细胞因子,信号通路”,英文检索词为“toll-like receptor,osteoblast,osteoclast,mesenchymal stem cells,macrophage,cytokine,signaling pathway”,并根据研究需要确立相应的标准,...
oxygen species (ROS). In addition, Toll-like receptor 4 (TLR4) receptor inhibitors were able to block the production of NO and TNF-α by SCP3-stimulated macrophages. Based on Western blot analysis and validation using specific inhibitors against MAPK and NF-κB signaling pathways, the results ...
The pathogenesis of pancreatitis has long been a hot topic in basic and clinical research but is still not fully clarified.Toll-like receptor 4(TLR4) recognizes the lipopolysaccharide(LPS) of Gram-negative bacteria and stimulates the synthesis and release of inflammatory cytokines through activation of...
signalingreceptortlrsliketlrpathways VIEWPOINTToll-LikeReceptorSignalingPathwaysGregoryM.BartonandRuslanMedzhitov*MembersoftheToll-likereceptor(TLR)familyrecognizeconservedmicrobialstruc-tures,suchasbacteriallipopolysaccharideandviraldouble-strandedRNA,andactivatesignalingpathwaysthatresultinimmuneresponsesagainstmicrobialinfectio...