Suppression of the aberrantly activated TNFA-NFKB pathway in the testicular niche of patients with nonobstructive azoospermia (NOA) restores spermatogonial stem cell self-renewal and expansiondoi:10.1016/j.fertnstert.2015.07.113Yango, P.L.University of California, San Francisco, San Francisco, CA;...
TRAF3 inactivation was correlated with an increasedNF-kB transcriptional signature and it was associated with activationof the non-canonical NFkB pathway. Additionally, we identifiedthe inactivation of TNFAIP3, another negative regulator of theNF-kB pathways, in one of 24 patients. Finally, ...
It is known that both canonical and non-canonical NF-kB pathways are implicated in autocrine production of TNFa in cancer cells.26,28 In this study, we investigated whether NF-kB pathway is involved in zVAD-induced autocrine production of TNFa. We first silenced I-kB kinase (IKKb) and ...
中国免疫学杂志 b-caryophyllene mitigates cerebral ischemia reperfusion injury in mice by inhibiting HMGB1/ TLR4/ NFkB pathway doi:10. 3969 / j. issn. 1000-484X. 2017. 07. 011 clinical and experimental pharmacology and physiology C1q/TNF‐related protein 9 improves the anti‐contractile effects ...
Tumor necrosis factor (TNFα) is a cytokine involved in Ang II signaling and promotes the inflammatory response via NF-kB. We hypothesized that activation of AT2 prevents TNFα stimulation of intercellular adhesion molecule-1 (ICAM-1) expression in human coronary artery endothelial cells (HCREC) ...
Furthermore, NF-kB-inhibition-induced APC apoptosis is dependent upon TNFa and leads to ROS formation. The accumulation of ROS results in the subsequent loss of mitochondrial membrane potential (DYm) and activation of the caspase-9/3 pathway. These data suggest a novel mechanism of NF-kB- ...
NF-jB activation pathway [97] NF-kB activation in Kupffer cells generally promotes liver injury because such activation results in the production of TNFa. However, NF-kB activation in hepatocytes gener- ally protects against liver injury because NF-kB upregu- lates the synthesis of several ...
中国免疫学杂志 b-caryophyllene mitigates cerebral ischemia reperfusion injury in mice by inhibiting HMGB1/ TLR4/ NFkB pathway doi:10. 3969 / j. issn. 1000-484X. 2017. 07. 011 clinical and experimental pharmacology and physiology C1q/TNF‐related protein 9 improves the anti‐contractile effects ...
Characterization of bovine A20 gene: Expression mediated by NF-kappa B pathway in MDBK cells infected with bovine viral diarrhea virus-1 In this study, the genetic context of bovine A20 was explored and compared against homologous genes in the human, mouse, chicken, dog, and zebrafish ... MOV...
A recent study by Lurje et al.49 reported multiple angiogenesis pathway polymorphisms in EC and verified the utility of SNPs for risk stratification in EC patients treated by surgery alone. Genome-wide association studies have identified several SNPs of the TNFAIP3 gene as risk alleles for ...