Suppression of the aberrantly activated TNFA-NFKB pathway in the testicular niche of patients with nonobstructive azoospermia (NOA) restores spermatogonial stem cell self-renewal and expansiondoi:10.1016/j.fertnstert.2015.07.113Yango, P.L.University of California, San Francisco, San Francisco, CA;...
Polygalasaponin F 可以调节 TLR4-PI3K/AKT-NF-kB 信号通路,下调神经炎症细胞因子的分泌,下调TNFa(肿瘤坏死因子 α )表达水平。 产品性质 英文别名 (English Synonym) Polygalasaponin F 中文名称 (Chinese Name) 瓜子金皂苷己 靶点 (Target) NF-κB 通路 (Pathway) Immunology/Inflammation CAS号 (CAS NO....
As TL1A-induced phosphorylation of nuclear factor-kB is part of the TL1A signaling pathway, we measured phosphorylation of nuclear factor-kB in CD4 þ T cells by intracellular phospho- flow cytometry.32 TL1A induced phospho-nuclear factor-kB in CD4 þ T cells within 10 min, which can ...
The ubiquitin editing enzyme A20 is a key negative regulator of NF-κB signaling. Moreover, A20 can also act as a strong antiapoptotic protein in specific cell types.7Because of the central role of A20 in controlling NF-κB and apoptotic responses, we sought to further clarify itsin vivorole...
中国免疫学杂志 b-caryophyllene mitigates cerebral ischemia reperfusion injury in mice by inhibiting HMGB1/ TLR4/ NFkB pathway doi:10. 3969 / j. issn. 1000-484X. 2017. 07. 011 clinical and experimental pharmacology and physiology C1q/TNF‐related protein 9 improves the anti‐contractile effects ...
Kaposi’s sarcoma-associated herpesvirus (KSHV) K13/vFLIP (viral Flice-inhibitory protein) induces transcription of numerous genes through NF-κB activation, including pro-inflammatory cytokines, which contribute to the pathogenesis of Kaposi’s sarcoma
Heat shock transcription factor 1 attenuates TNFa-induced cardiomyocyte death through suppression of NFkB pathwayGENE -AMSTERDAM-L.C.HuangM.JiangTangJ.
In the current study, we examined the ability of TNFα to induce dysregulation of microRNAs (miRNAs) linked to NFkB signal- ing pathways, thus contributing to the pathogenesis of endometriosis. Using RT-qPCR, the expression of several miRNAs was quantified in primary cells derived from eutopic ...
A20, also known as TNF-alpha-induced protein3 (TNFAIP3), is a well-known negative regulator of the NF-kB activation pathway (Coornaert et al.2009; Stilo et al.2008) and functions as a tumor suppressor gene in lymphomas (Honma et al.2009; Kato et al.2009). Aberrant NF-kB regulation...
Polymorphisms in the inflammatory pathway genes TLR2, TLR4, TLR9, LY96, NFKBIA, NFKB1, TNFA, TNFRSF1A, IL6R, IL10, IL23R, PTPN22, and PPARG are associated with susceptibility of inflammatory bowel disease in a Danish cohort. PLoS One. 2014;9(6):e98815....