In recent years, it became clear that TNF drives inflammatory responses not only directly by inducing inflammatory gene expression but also indirectly by inducing cell death, instigating inflammatory immune reactions and disease development. Hence, inhibitors of cell death are being considered as a new...
Current cell-based drug screening technologies utilize randomly integrated reporter genes to index transcriptional activity of an endogenous gene of interest. In this context, reporter expression is controlled by known genetic elements that may only partially capture gene regulation and by unknown features...
Full size image RPE barrier function is enabled by apical tight-junctions, thus we investigated junctional integrity by visualization of the marker Zonula occludens-1 (ZO-1). Under unchallenged conditions, RPE cells form a characteristic cobblestone monolayer with defined cell borders (Fig. 2C). ...
Laboratory Investigation (2011) 91, 328–341 & 2011 USCAP, Inc All rights reserved 0023-6837/11 $32.00 TNF gene cluster deletion abolishes lipopolysaccharide-mediated sensitization of the neonatal brain to hypoxic ischemic insult Giles S Kendall1, Mariya Hirstova1, Sigrun Horn2, Dimitra Dafou3, ...
and negative regulation of gene expression. The extracellular domain of TNFR1 is also released into the circulatory system as soluble TNFR1 (sTNFR1). In humans, the TNFR1 gene is located on chromosome 12. Anti-apoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins ...
highlighting positively and negatively selected perturbations. Full list in Extended Data Fig.8a.d, EMT is induced in positively selected perturbations in the P60 skin, identified through differential gene expression between positively and negatively selected perturbations.e, Schematic of lentiviral vector ...
et al. Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR. Nat. Immunol. 19, 291–301 (2018). Article CAS PubMed PubMed Central Google Scholar Lubrano di Ricco, M. et al. Tumor necrosis factor receptor family costimulation increases regulatory...
Research article: http://mcb.asm.org/cgi/content/full/24/22/9752 tBID A truncated form of cytosolic BID that translocates to mitochondria. Produced as a result of TNFR1/Fas engagement T-box genes The T-box gene family codes for transcription factors (and putative transcription factors) that...
of receptor binding, signalling pathway interactions and gene expression. Whilst each of these signalling events is transient, precise regulation is required as the resulting cell-fate decision is often irreversible. The most fundamental decision is binary: should a cell survive or commit to apoptosis...
and antiviral responses. LTA is also involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Gene Symbol: TNF-Beta; tumor necrosis factor-Beta; Tumor necrosis factor ligand superfamily member 1; TNFSF1; LTA; Lymphotoxin-alpha; TNF-beta; LT-alpha...