TNF-alpha and IFN-gamma regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells.Physics - Plasma PhysicsBACKGROUND & AIMS: NOD2, a member of the NOD1/Apaf-1 family, was recently identified as the first susceptibility gene for Crohn's disease. The aim of ...
Entrez Gene IDs 7124 (Human); 21926 (Mouse); 24835 (Rat); 397086 (Porcine); 280943 (Bovine); 403922 (Canine); 102139631 (Cynomolgus Monkey); 100033834 (Equine); 493755 (Feline); 100009088 (Rabbit) Alternate Names APC1 protein, Cachectin, Cachetin, DIF, TNF, TNF, monocyte-derived, TNF...
Gene Name TNF Full Name Tumor necrosis factor Weight 25644 MW Superfamily Tumor necrosis factor family Alternative Names Tumor necrosis factor;Cachectin;TNF-alpha;Tumor necrosis factor ligand superfamily member 2;TNF-a;Tumor necrosis factor, membrane form;N-terminal fragment;NTF;Intracellular domain 1;...
Another poly- morphism in NOD2/CARD15 gene has been linked to CD and may influence the response to anti-TNF-alpha therapy in individuals with this mutation, while poly- morphisms in the IL23 receptor have been linked to the response to Infliximab treatment in UC patients [31]. In ...
The term “immunoglobulin” is used herein to refer to a protein comprising of one or more polypeptides substantially encoded by immunoglobulin genes. The recognized immunoglobulin heavy chain constant region gene isotypes include IgG, (subtypes IgG1, IgG2, IgG3, and IgG4), IgM, IgA (subtypes ...
Using a candidate gene approach in this case-control study, 51 mainly functional single nucleotide polymorphisms (SNPs) in genes regulating inflammation were assessed in 709 patients with AS and 795 controls. Data on the patients with AS were obtained from the DANBIO registry where patients from ...
Entrez Gene IDs7124 (Human); 21926 (Mouse); 24835 (Rat); 397086 (Porcine); 280943 (Bovine); 403922 (Canine); 102139631 (Cynomolgus Monkey); 100033834 (Equine); 493755 (Feline); 100009088 (Rabbit) Alternate NamesAPC1 protein, Cachectin, Cachetin, DIF, TNF, TNF, monocyte-derived, TNF-A,...