TNF-alpha and IFN-gamma regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells.Physics - Plasma PhysicsBACKGROUND & AIMS: NOD2, a member of the NOD1/Apaf-1 family, was recently identified as the first susceptibility gene for Crohn's disease. The aim of ...
Using a candidate gene approach in this case-control study, 51 mainly functional single nucleotide polymorphisms (SNPs) in genes regulating inflammation were assessed in 709 patients with AS and 795 controls. Data on the patients with AS were obtained from the DANBIO registry where patients from a...
Entrez Gene IDs 7124 (Human); 21926 (Mouse); 24835 (Rat); 397086 (Porcine); 280943 (Bovine); 403922 (Canine); 102139631 (Cynomolgus Monkey); 100033834 (Equine); 493755 (Feline); 100009088 (Rabbit) Alternate Names APC1 protein, Cachectin, Cachetin, DIF, TNF, TNF, monocyte-de...
Entrez Gene IDs7124 (Human); 21926 (Mouse); 24835 (Rat); 397086 (Porcine); 280943 (Bovine); 403922 (Canine); 102139631 (Cynomolgus Monkey); 100033834 (Equine); 493755 (Feline); 100009088 (Rabbit) Alternate NamesAPC1 protein, Cachectin, Cachetin, DIF, TNF, TNF, monocyte-derived, TNF-A,...
Haploid Yeast Cell: A cell having a single copy of each gene of its normal genomic (chromosomal) complement. Polyploid Yeast Cell: A cell having more than one copy of its normal genomic (chromosomal) complement. Diploid Yeast Cell: A cell having two copies (alleles) of essentially every gene...
CARD15 mutationinfliximabmonozygotic twinsTNF‐α inhibitorBlau syndrome is a hereditary granulomatous disease caused by mutations in the CARD15 gene that is diagnosed in children of young age with exanthema/erythema, arthritis/periarthritis and/or uveitis. We report two cases of Blau syndrome in ...
(-308G/A) gene polymorphism on circulatingTNF-αlevels following continuous positive airway pressure (CPAP) therapy. Methods: This study was a secondary analysis of the RICCADSA trial (NCT00519597) conducted in Sweden. CAD patients with OSA (apnea–hypopnea index) of ≥15 events/h and an ...
Potential pathophysiological hypotheses include that the introduction of TNF alpha blockers may alter the cytokine balance in patients with a genetic predisposition, having genetic factors like NOD2/CARD15 gene mutations, which may result in background conditions for the development of IBD [3]. ...