Gene Expression Profiling of the Hepatic Transcriptome in Presence of TNF-alphaDiabetes mellitus, often simply termed Diabetes, is a syndrome characterized by disordered metabolism and high blood sugar. It is caused due to low levels of insulin hormone or from abnormal resistance to insulin in its ...
As an alternative technology, we applied highly efficient gene-targeting with recombinant adeno-associated virus to precisely integrate a luciferase reporter gene into exon 1 of the HeLa cell tumor necrosis factor-alpha (TNF-α) gene. Drugs known to induce TNF-α expression were then used to ...
[9] Leon LR. Invited review: cytokine regulation of fever: studies using gene knockout mice[J]. J Appl Physiol, 2002, 92(6): 2648-2655. DOI:10.1152/ japplphysiol.01005.2001. [10] Schett G, Dayer JM, Manger B. ...
TNFalpha Tnfsf1a tumor necrosis factor-alpha tumor necrosis factor, alpha 基因序列:NCBI_Gene:21926 蛋白序列: UniprotKB:P06804 UniprotKB:A0A0R4J210 UniprotKB:A0A0U5J4W4 UniprotKB:Q3U4I6 UniprotKB:Q3U593 UniprotKB:Q6TDG3 小鼠Mouse Tnf 靶点分子功能(预测) ...
此外,由 LTA基因编码的同样隶属于TNSF超家族的TNF-β蛋白,也称为淋巴毒素α(Lymphotoxin Alpha,LT-α),也能与TNFR1和TNFR2相结合。 图2. TNFR1与TNFR2介导的信号通路[3] 小结 作为一种细胞因子,TNF-α在免疫反应中发挥了重要作用,包括促进炎症反应、细胞增殖和分化、细胞凋亡和坏死等。此外,TNF-α的过表达...
Protein tyrosine kinase (PTK) activity has been implicated in pro-inflammatory gene expression following tumor necrosis factor-α (TNF-α) or interkeukin-1β (IL-1β) stimulation. However, the identity of responsible PTK(s) in cytokine signaling have not been elucidated. To evaluate which PTK...
基因别名: DIF; TNF; TNF-alpha; TNFA; TNFSF2; TNLG1F UniProt ID: (Human) P01375 Entrez Gene ID: (Human) 7124 功能 protease binding cytokine activity tumor necrosis factor receptor binding protein binding identical protein binding transcription regulatory region DNA binding 参与通路 protein...
(TNF-α) gene expression induced by tumor promoters, okadaic acid and 12-O-tetradecanoylphorbol-13-acetate, associated with reduction of NF- B DNA ... Sueoka,E.,N.,... - 《Biochemical & Biophysical Research Communications》 被引量: 97发表: 1998年 Tumor promoters: from chemicals to inflammat...
TNF-alpha Tnfa TNFalpha Tnfsf1a tumor necrosis factor-alpha tumor necrosis factor, alpha 基因序列:NCBI_Gene:21926 蛋白序列: UniprotKB:P06804 UniprotKB:A0A0R4J210 UniprotKB:A0A0U5J4W4 UniprotKB:Q3U4I6 UniprotKB:Q3U593 UniprotKB:Q6TDG3
In previous studies, the resistance to infection by Trypanosoma congolense has been localized in a region of chromosome 17 consisting the gene of TNF alpha. On the other hand, it has been Reported that the TNF alpha has a trypanolitic activity. So, we have started to study the expression ...