TNF and TNFR biology in health and disease. Many insights have been gained into cytokine-regulated control of inflammatory processes and host defence in recent years. Evidence has also gradually accu... McDermott,F M. - Cell Mol Biol (Noisy-le-grand). 被引量: 333发表: 2001年 Association ...
Targeting the TNF and TNFR superfamilies in autoimmune disease and cancer. Nat Rev Drug Discov 23, 939–961 (2024). https://doi.org/10.1038/s41573-024-01053-9 Download citation Accepted09 September 2024 Published24 October 2024 Issue DateDecember 2024 DOIhttps://doi.org/10.1038/s41573-024-...
Targeting the TNF and TNFR superfamilies in autoimmune disease and cancer Article 24 October 2024 Interleukin-2 and regulatory T cells in rheumatic diseases Article 02 November 2021 References Feldmann, M. Translating molecular insights in autoimmunity into effective therapy. Annu. Rev. Immunol. ...
This review seeks to elucidate the therapeutic potential of tumor necrosis factor receptor 1 (TNFR1) and enhance our comprehension of its role in disease mechanisms. As a critical cell-surface receptor, TNFR1 regulates key signaling pathways, such as nuclear factor kappa-B (NF-魏B) and mitogen...
CD30 TNFRSF8 Ki-1, D1S166E M83554 1p36 4, 75.5 cM Marker of Reed-Sternberg cells in Hodgkin's disease HveA TNFRSF14 HVEM, ATAR, TR2, LIGHTR U70321 1p36.3-p36.2 Probable role in T cell proliferation and receptor for herpes simplex virus 4-1BB TNFRSF9 CD137, ILA L12964 1p36 4...
Advances in Experimental Medicine and BiologySchreiber TH, Wolf D, Podack ER (2011) The role of TNFRSF25:TNFSF15 in disease... and health? Adv Exp Med Biol 691: 289-298.Schreiber, T. H., D. Wolf, and E. R. Podack. 2011. The role of TNFRSF25: TNFSF15 in disease... and ...
TNFR2 comprises four cysteine-rich domains, CRD1, CRD2, CRD3 and CRD4 [109]. The CRD1, also known as pre-ligand assembly domain (PLAD), primarily involved in TNFR self-assembly on the cell surface. The CRD 2 and CRD3 domains are considered responsible for binding to tumor necrosis fac...
与TNFR1不同,TNFR2主要与mTNF-α结合,且TNFR2的胞质尾不含DD,能直接与肿瘤坏死受体相关因子1(TNFR associated factor 1,TRAF1)和肿瘤坏死受体相关因子2(TNFR associated factor 2 ,TRAF2)相互作用,在稳态信号下诱导复合物 I 的形成,激活NF-κB通路,促进细胞存活。
与TNFR1不同,TNFR2主要与mTNF-α结合,且TNFR2的胞质尾不含DD,能直接与肿瘤坏死受体相关因子1(TNFR associated factor 1,TRAF1)和肿瘤坏死受体相关因子2(TNFR associated factor 2 ,TRAF2)相互作用,在稳态信号下诱导复合物 I 的形成,激活NF-κB通路,促进细胞存活。
[240] revealed that tumour cells upregulate PD-L1 expression to suppress secretion of TNF and cell killing by CLs. Kearney et al. [241] further demonstrated that loss of the TNF/TNFR1 signalling componentsCasp8andTnfrsf1aincreases resistance to CD8 + T cell- and natural killer cell-...