AXL targeting restores PD-1 blockade sensitivity of STK11/LKB1 mutant NSCLC through expansion of TCF1 CD8 T cells.Cell Rep Med. 2022 [17] Selective delivery of low-affinity IL-2 to PD-1+ T cells rejuvenates antitu...
Fig. 7 | ERrichRA T cells are TNF superproducers. Naïve CD4+CD45RA+T cells from patients with RA and age-matched controls were stimulated for 72 h. a, Representative confocal image of the ER chaperone protein calnex...
T-cell cytotoxicity of human Schwann cells: TNFalpha promotes FasL-mediated apoptosis and IFN gamma perforin- mediated lysis. Glia 2003;43(2):141-8.Bonetti B, Valdo P, Ossi G, De Toni L, Masotto B, Marconi S, Rizzuto N, Nardelli E, Moretto G. T cell cytotoxicity of human Schwann ...
1.Max Dale Cooper et al. Discovery of 2 Distinctive Lineages of Lymphocytes, T Cells and B Cells, as the Basis of the Adaptive Immune System and Immunologic Function. JAMA, 2019, doi:10.1001/jama.2019.13815. 2.Simon Heidegger et al. RIG-I activation is critical for responsiveness to checkpo...
《TNFR2+调节性T细胞在肺癌免疫耐受中的作用及机制研究》是依托天津医科大学，由赵华担任项目负责人的青年科学基金项目。中文摘要 调节性T细胞（Regulatory T cells, Treg）是肿瘤免疫逃逸的主要机制之一。新的肿瘤治疗策略应在刺激效应性T细胞的同时清除Treg。已知75%-100%的小鼠肿瘤浸润Treg表达TNFR2，且CD4+TNFR2...
随后，研究人员还做了一系列的实验，研究 TRAF2 对于 免疫系统的影响，尤其是 T 细胞的影响。根据实验结果，得出结论，TRAF2 的失活重新引导 TNF 信号通路，从而有利于 RIPK1-dependent 细胞的死亡，进而让 T 细胞更有效地杀死肿瘤细胞。Figure 4. TRAF2 Targeting Poises Cells to Undergo RIPK1-Dependent Cell ...
首先,TNF-α可促进白细胞的募集,使其便于产生其他的促炎细胞因子和趋化因子,并激活中性粒细胞参与常规 T 细胞的共刺激。其次,TNF-α具有调节活性,例如抑制造血、增加糖皮质激素的产生以及改变树突状细胞和巨噬细胞的功能等。另外,TNF-α 还可以通过促进B 细胞产生IL-10、诱导 T 细胞凋亡、改变T细胞受体(TCR)信号...
Misdirected immunity gives rise to the autoimmune tissue inflammation of rheumatoid arthritis, in which excess production of the cytokine tumor necrosis factor (TNF) is a central pathogenic event. Mechanisms underlying the break...
1.Max Dale Cooper et al. Discovery of 2 Distinctive Lineages of Lymphocytes, T Cells and B Cells, as the Basis of the Adaptive Immune System and Immunologic Function. JAMA, 2019, doi:10.1001/jama.2019.13815. 2.Simon Heidegger ...