肿瘤坏死因子alpha(TNF-α)是一种由157个氨基酸组成的 17-kDa 蛋白质,为免疫细胞产生的多功能细胞因子,在细胞凋亡和存活以及免疫和炎症中发挥关键作用[1]。 它主要由活化的巨噬细胞、T 淋巴细胞和自然杀伤 (NK) 细胞分泌,但是在包括成纤维细胞,平滑肌细胞...
肿瘤坏死因子alpha(TNF-α)是一种由157个氨基酸组成的 17-kDa 蛋白质,为免疫细胞产生的多功能细胞因子,在细胞凋亡和存活以及免疫和炎症中发挥关键作用[1]。 它主要由活化的巨噬细胞、T 淋巴细胞和自然杀伤 (NK) 细胞分泌,但是在包括成纤维细胞,平滑肌细胞...
Recombinant Mouse TNF-αproteinwas measured by NF-κB reporter assay in HEK293 cells .The ED50 for this effect is 40-200 pg/mL. RP00993 Recombinant Human TNF-alpha 表达系统:HEK293 标签:C-6His 纯度测定: 活性测试: Recombinant Human TNF-alpha induces cytotoxicity in the L-929 mouse fibroblas...
活性测试: Recombinant Human TNF-alpha induces cytotoxicity in the L-929 mouse fibroblast cell line in the presence of the metabolic inhibitor actinomycin D.The ED50 for this effect is typically 25-100 pg/mL. Recombinant Human TNF-alpha induces cytotoxicity in the L-929 mouse fibroblast cells in...
产品活性:肿瘤坏死因子 α (TNF alpha) 是一种有效的促炎细胞因子。TNF alpha 与其受体结合,主要是 TNFR1 和 TNFR2,然后传递信号以实现炎症和细胞死亡等生物学功能。TNF alpha 通过 TNFR2 受体激活 NF-κB 通路促进癌细胞生长、侵袭和转移,但抗 TNF-α 抗体能显着抑制结肠炎相关癌症 (CAC) 小鼠的肿瘤发展。
TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon-gamma in its cytotoxicity. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. 仅用于科研。不用于诊断过程。未经明确授权不得...
DBA/1 mice expressing the human TNF-alpha transgene develop a severe, erosive arthritis: characterization of the cytokine cascade and cellular composition. J Immunol. 1997 Sep 15;159(6):2867-76. [9]Inglis JJ, Criado G, Medghalchi M, Andrews M, Sandison A, Feldmann M, Williams RO. ...
TNF alpha (小鼠) (1, 10; 100 ng/mL; 48 h) 在 1 ng/mL 和高浓度 (10 和 100 ng/ml) 下诱导细胞增殖,在 SVZ 细胞中诱导细胞凋亡 [4]. 研究背景:TNF α 由巨噬细胞、单核细胞、中性粒细胞、T 细胞和 NK 细胞等多种细胞产生[2]。人 TNF α 蛋白的氨基酸序列同源性较低小鼠、大鼠、牛、食...
重组大鼠肿瘤坏死因子-alpha(TNF-alpha) 英文名称: 总访问: 1064 国产/进口: 进口 半年访问: 7 产地/品牌: prospec 产品类别: 细胞生物学试剂 规格: 5 µg,货号:CYT-393 最后更新: 2024-12-5 货号: CAS 号: 参考报价: 700 立即询价 电话咨询 ...
TNF-α is mainly produced by activated monocytes, macrophages, and T cells. It is first synthesized as a membrane-bound molecule that forms a compact homotrimer through non-covalent interactions. The trimeric membrane-bound form is cleaved by tumor necrosis factor-alpha converting enzyme (TACE) re...