Role for TNF in CNS Inflammation, Demyelination and Neurodegeneration Studied in Transgenic MiceTumor necrosis factor (TNF) is a pluripotent cytokine which is be-lieved to play a central role in the pathogenesis of human im-mune-mediated diseases. In neuroimmunologic diseases TNF is produced ...
What is the role of TNF in inflammation? TNF is an important signal that controls inflammation in your body. If your TNF levels are low, you'll have less inflammation. When your levels are high, you'll have more inflammation. Normally, TNF should go up and turn inflammation on when you...
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Tumor Necrosis Factor (TNF) has a crucial role in inflammation, cell proliferation and cell death. Dysregulation of TNF receptor 1 (TNFR1)-induced Nuclear Factor-kappa B (NF-κB) signaling leads to chronic inflammation and is associated with several human inflammatory pathologies. Hence, TNF neutr...
Both TNF-induced oxidative stress and inflammation interact and cooperate to promote neurodegeneration. However, TNF plays a dual role in neurodegenerative disease, since stimulation via its second receptor, TNFR2, is neuroprotective and promotes tissue regeneration. Here we review the interrelation of ...
Acute pancreatitis (AP) is an inflammatory disease with varied severity, ranging from mild local inflammation to severe systemic involvement resulting in s... P Dumnicka,D Maduzia,P Ceranowicz,... - 《International Journal of Molecular Sciences》 被引量: 23发表: 2017年 The role of Th17 cel...
The pro-inflammatory cytokine TNF is a key disease driver in a variety of autoimmune and autoinflammatory diseases, including rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and psoriasis (PsO). Its pivotal role has been demonstrated most relevantly by the clinical success of TNF-bloc...
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Tumor necrosis factor-alpha (TNF-α) plays an important role in the developing process of inflammatory bowel disease. Tight junction protein zonula occludens-1 (ZO-1), one of epithelial junctional proteins, maintains the permeability of intestinal barrier. The objective of this study was to invest...