Increased serum concentrations of tumor necrosis factor a (TNF alpha) and transforming growth factor beta-1 (TGF beta-1) in the blood of patients with pancreatic cancer (PC) have previously been demonstrated. In addition, exogenous exposure to these cytokines promotes various cancer cell invasive ...
In control day 1 or day 3 cultures, TNF-alpha and/or TGF-beta1 had little or no effect on the synthesis of type II cellular proteins, independent of whether the cells were exposed to dust. With PSOC 867 exposure, where ECM protein synthesis is elevated, TNF-alpha and TGF-beta1 further...
TGF beta-1 and TNF alpha expression in the epidermis of patients with epidermodysplasia verruciformis. J Invest Dermatol. 1991; 97 :862–867.Majewski S, Hunzelmann N, Nischt R, et al. TGFβ-1 and TNFα expression in the epidermis of patients with epidermodysplasia verruciformis. J ...
结果:TGF-β1、TNF-α和MMP-9在活动性淋巴结核组和陈旧性淋巴结核组均有表达,三者在活动性淋巴结结核的肉芽肿、坏死周围炎区呈强表达,慢性非特异性淋巴结炎组呈弱阳性表达.TGF-β1和MMP-9在结节病组呈中等度表达,而TNF-α在结节病组不表达.三者在正常淋巴结中不表达.三者的表达在活动性结核组显著...
The production of IL-6, TNF-and TGF-continuously increased 96 hrs after stimulation of LPS. The amount of production was 19.8 ng/ml of IL-6 by PBMC, 4.1 ng/mL of TNF by PBMC and 34.4 pg/mL of TGF-by PBMC. The immunoreactivity to IL-6, TNF-and TGF-were detected on monocytes in...
Recently we reported that TNFalpha activates the extracellular regulated kinase pathway in fibroblasts leading to a 200-400% increase in TGFbeta(1) mRNA and protein. The mechanism of TNFalpha induction of TGFbeta(1) expression appears to be complex, involving both transcriptional and post-...
Circulating TNF-alpha, TGF-beta, and IL-10 in tuberculosis patients and healthy contacts. Levels of tumour necrosis factor (TNF)-±, transforming growth factor (TGF)-, and interleukin (IL)-10 in plasma of pulmonary tuberculosis (TB) patients and... J. O.Olobo,M.Geletu,A.Demissie,......
In addition, Tat treatment results in increased levels of TGFbeta-1 and TNFalpha mRNAs in these cells. Activation of the TGFbeta-1 and TNFalpha promoter constructs by Tat in U-87MG and SK-N-MC cells required amino acid residues 2 to 36 which spans the acidic and the cysteine-rich ...
TNF-alpha and TGF-beta1 regulate syndecan-4 expression in nucleus pulposus cells: Role of the mitogen-activated protein kinase and NF-kappaB pathways. Connect. Tissue Res. 2015, 56, 281-287. [CrossRef] [PubMed]
Transforming growth factor beta 1(TGF-beta1) down-regulates TNFalpha-induced RANTES production in rheumatoid synovial fibroblasts through NF-kappaB-mediate... Transforming growth factor beta 1(TGF-beta1) down-regulates TNFalpha-induced RANTES production in rheumatoid synovial fibroblasts through NF- ...