Increased serum concentrations of tumor necrosis factor a (TNF alpha) and transforming growth factor beta-1 (TGF beta-1) in the blood of patients with pancreatic cancer (PC) have previously been demonstrated. In addition, exogenous exposure to these cytokines promotes various cancer cell invasive ...
In control day 1 or day 3 cultures, TNF-alpha and/or TGF-beta1 had little or no effect on the synthesis of type II cellular proteins, independent of whether the cells were exposed to dust. With PSOC 867 exposure, where ECM protein synthesis is elevated, TNF-alpha and TGF-beta1 further...
TGF beta-1 and TNF alpha expression in the epidermis of patients with epidermodysplasia verruciformis. J Invest Dermatol. 1991; 97 :862–867.Majewski S, Hunzelmann N, Nischt R, et al. TGFβ-1 and TNFα expression in the epidermis of patients with epidermodysplasia verruciformis. J ...
摘要: Tuberculosis (TB) is the main cause of death by infection diseases worldwide. Considering that NO, TNF-alpha and TGF-beta participate a great deal in TB immunopathogenesis, we wished to a DOI: doi:10.1016/j.imlet.2004.09.008 被引量: 16 年份: 2005 收藏...
结果:TGF-β1、TNF-α和MMP-9在活动性淋巴结核组和陈旧性淋巴结核组均有表达,三者在活动性淋巴结结核的肉芽肿、坏死周围炎区呈强表达,慢性非特异性淋巴结炎组呈弱阳性表达.TGF-β1和MMP-9在结节病组呈中等度表达,而TNF-α在结节病组不表达.三者在正常淋巴结中不表达.三者的表达在活动性结核组显著...
Transforming growth factor-beta stimulates the production of the extracellular matrix, whereas TNF-alpha has antifibrotic activity. Understanding the molecular mechanism underlying the antagonistic activities of TNF-alpha against TGF-beta is critical in the context of tissue repair and maintenance of tissue...
Recently we reported that TNFalpha activates the extracellular regulated kinase pathway in fibroblasts leading to a 200-400% increase in TGFbeta(1) mRNA and protein. The mechanism of TNFalpha induction of TGFbeta(1) expression appears to be complex, involving both transcriptional and post-...
We designated this region the TGF beta -responsive element (TbRE) and revealed that a ubiquitous trans-activator Sp1 and unknown nuclear factor(s) b 展开 关键词: collagen gene transcriptional regulation hepatic fibrogenesis TGF beta Smad DOI: 10.1016/S0168-8278(02)80231-8 ...
The Journal of experimental medicine 1999 - Figure 3 CT treatment selectively suppressed IL-12 p70 and TNF-alpha, but not IL-10, TGF-beta 1 , or IL-6. Human monocytes (2 x 10 6 cell/mL) were stimulated with SAC (0.01%) and IFN-gamma (100 ng/mL) in the presence or absence of ...
R&D 240-B-002 R&D Recombinant Human TGF-beta 1. kit 3150 R&D 236-EG-200 R&D Recombinant Human EGF, CF kit 1580 R&D 233-FB-025 R&D Recombinant Human FGF basic(146 aa):25ug 25ug 2270 R&D MAB2020 R&D Human/Rat OV-6 MAb (Clone OV-6) kit 3720 R&D 215-GM-010 R&D Recombinant Human ...