细胞中 TGF-β 信号传导的多样性不仅取决于各种配体、受体、SMAD 介质或 SMAD 相互作用蛋白，还取决于 TGF-β 激活其他信号通路的能力。在非经典途径中，TGFβ 受体复合物通过其他因子传递信号，如 TRAF4 或 TRAF6、TAK1、p38 MAPK、RHO、PI3K-AKT，ERK、JNK 或 NF-KB，间接参与细胞凋亡、上皮-间充质转化、迁...
NF-kBSpecific study about the inhibitory effect of costunolide (CN) and relevant mechanism is of great significance for the treatment of pulmonary fibrosis. Here, the pharmacological activity of costunolide on the treatment of pulmonary fibrosis was investigated in vivo and in vitro. The in vivo ...
Transforming growth factor beta stimulates the human immunodeficiency virus 1 enhancer and requires NF-kappaB activity. Mol. Cell Biol. 1998 Jan; 18(1): 110-21. PubMed ID: 9418859 * Review: Cell proliferation in somatic tissues, specification of cell fate during embryogenesis, differentiation and...
品牌默克密理博/Millipore 单件重量0kg 货期15天 单位:盒包装:盒库存:0 数量:盒+-1盒起订,增量1盒 累计成交1笔0条评价 选择其它规格 商品名 贝雷猫货号 原厂编号 品牌 商品规格 单位 货期 价格 库存 购买 RH169913 AB9263 默克密理博/Millipore Rb X P2Y1 ...
Effects of interferon plus ribavirin treatment on NF-kB, TGF-β1, and metalloproteinase activity in chronic hepatitis C. Modern Pathology., 19: 1047-1054.Guido M, De Franceschi L, Olivari N, Leandro G, Felder M, Corrocher R, et al. Effects of interferon plus ribavirin treatment on NF-...
例如,NFKB 105亚单位是B细胞中基因的一种多肽基因增强子。FAS配体和其他配体与受体结合,用于信号传导途径,例如凋亡或JNK信号传导。受体激动剂经常被用于药物开发,受体是1型、2型或3型配体结合因子和从细胞外接收化学信号的蛋白质分子。当这些化学信号与受体结合或结合时,它们会引起某种形式的细胞/组织反应,例如细胞电...
Figure 6.Over-expression ofLnc-Nr6a1. (A) Diagram of CRISPR SAM-CRISPR/Cas9 activation system. Nuclease-dead Cas9 (dCas9), fused to the transcriptional activator VP64, complexes with the CRISPR guide RNA. MS2 bacteriophage coat protein is fused to the p65 subunit of NF-kappaB and the activ...
Polarized secretion of CXC chemokines by human intestinal epithelial cells in response to Bacteroides fragilis enterotoxin: NF- κ B plays a major role in ... by human intestinal epithelial cells in response to Bacteroides fragilis enterotoxin:NF-kappa B plays a major role in the regulation of IL...
Sodium selenite inhibits the expression of VEGF, TGFbeta(1) and IL-6 induced by LPS in human PC3 cells via TLR4-NF-(K)B signaling blockage. Lipopolysaccharide (LPS)-induced TLR4-NF- KB signaling plays an important role in the development of prostatic tumors from chronic bacterial prostatic in...
描述:Aplha、转录相关生长因子和刺激因子或抑制核因子是参与细胞分化的蛋白质的复杂亚单位。复合亚单位相关因子参与了杂交瘤的生长、嗜酸性粒细胞、厄立特里亚的增殖,并来源于DNA结合复合物上的启动子结合刺激亚单位。例如,NFKB 105亚单位是B细胞基因的多聚体基因增强子。