Eprotirome (KB2115) 是肝脏选择性甲状腺激素受体 (thyroid hormone receptor, TR) 激动剂。KB2115 对TRβ的亲和力略高于TRα。Eprotirome 降低了低密度脂蛋白 (LDL) 胆固醇的浓度,可用于血脂异常和肥胖症的研究。 MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务 ...
Described herein are methods and compositions for the treatment of conditions, diseases, or disorders associated with thyroid hormone receptor activity. The methods and compositions disclosed herein include the use of at least one thyroid hormone receptor agonist.BOHAN JIN...
From the structure, it became apparent that thyroid hormone is tightly packed inside the receptor molecule and that the last few amino acids of the receptor protein form an α-helix (helix 12), which acts as a kind of lid to close the box in which the hormone fits snugly. It has also...
查看相关系列 TSH receptor Agonist Skip to the end of the images gallery Skip to the beginning of the images gallery 基本描述 产品名称 TSH, 促甲状腺激素受体激动剂 别名 Thyrogen,thyroid-stimulating hormone;thyrotropin 英文别名 Thyrogen,thyroid-stimulating hormone;thyrotropin 规格或纯度 Moligand™...
Thyroid Hormone Receptor There are two TR genes,TRαandTRβ, located onchromosomes 17and 3, respectively. Both genes produce twoisoforms,TRα1andTRα2byalternative splicing, andTRβ1andTRβ2by utilization of differenttranscription start sites. TR binds as amonomer, or with greater affinity asho...
Since systemic side effects of T3 may preclude its clinical use, and hepatocytes mostly express T3 hormone receptor β (TRβ), we investigated if selective TRβ agonists like GC-1 may also have β-catenin-dependent hepatocyte mitogenic effects. Here we studied the effect of GC-1 and T3 in ...
Synthesis and preclinical testing of a selective beta-subtype agonist of thyroid hormone receptor ZTA-261 Article Open access 06 August 2024 References JF, C. Discovery of a new cure for goiter [De´- couverte d’un nouveau reme’de contre le goıˆtre]. Ann Chim Phys Paris 15, ...
expression system capable of producing the polypeptide fragments thereof For example, one can determine the active domain of a glycoprotein hormone which, together with a β-subunit, can interact with a glycoprotein hormone receptor and cause a biological effect associated with the glycoprotein hormone....
相似文献 参考文献 引证文献来源期刊 Hepatology: Official Journal of the American Association for the Study of Liver Diseases 研究点推荐 NON-ALCOHOLIC STEATOHEPATITIS (NASH) THYROID HORMONE RECEPTOR 辅助模式 0 引用 文献可以批量引用啦~欢迎点我试用!
Despite efforts spanning four decades, the therapeutic potential of thyroid hormone receptor (TR) agonists as lipid-lowering and anti-obesity agents remains largely unexplored in humans because of dose-limiting cardiac effects and effects on the thyroid hormone axis (THA), muscle metabolism, and bone...