Thyroid Hormone Receptor-beta Agonist GC-1 Inhibits Met-beta-Catenin-Driven Hepatocellular Cancer. Am J Pathol. 2017;187(11):2473-85.Puliga E, Min Q, Tao J, Zhang R, Pradhan-Sundd T, Poddar M, et al. Thyroid hormone receptor-β agonist GC-1 inhibits Met-β- catenin-driven ...
The preovulatory surge of luteinizing hormone reaches a maximum at 18.00 h on the day of pro-oestrus in female rats maintained with regular lighting from 0... CW Coen,MC Coombs - 《Neuroscience》 被引量: 122发表: 1983年 Epiquinamide: a poison that wasn't from a frog that was. In 200...
Thyroid hormones regulate cell growth, cell differentiation, and metabolic functions via interaction with the thyroid hormone nuclear receptors (TRs). Recently, a small class of halogen-free high-affinity thyroid hormone agonists has been developed that are highly selective for the TRbeta subtype. Beca...
Since systemic side effects of T3 may preclude its clinical use, and hepatocytes mostly express T3 hormone receptor beta (TRbeta), we investigated if selective TRbeta agonists like GC-1 may also have beta-catenin-dependent hepatocyte mitogenic effects. Here we studied the effect of GC-1 and ...
Resmetirom(MGL-3196) | Resmetirom (MGL-3196) is an orally active thyroid hormone receptor-beta (THR-beta) agonist with high specific uptake in liver. Selectivity for THR-beta may provide metabolic benefits of thyroid hormones in managing MASH. 链接 ...
M. et al. Thyroid hormone receptor beta-specific agonist GC-1 increases energy expenditure and prevents fat-mass accumulation in rats. J. Endocrinol. 193, 21–29 (2007). 24. Lin, J. Z. et al. Pharmacological Activation of Thyroid Hormone Receptors Elicits a Functional Conversion of White ...
1.4Thyroid Hormone Receptors Thyroid hormone receptor(THR):There are two types ofTHR, alpha and beta (THRA and THRB), encoded by separate genes, and the proteins are highly conserved in vertebrates (Brent, 2012; Cheng et al., 2010). The humanTHRAgene has alternative splice products to yield...
In vitro assay for human thyroid hormone receptor β agonist and antagonist effects of individual polychlorinated naphthalenes and Halowax mixtures 来自 Springer 喜欢 0 阅读量: 49 摘要: mol/L 3,3',5-triiodo-L-thyronine, which induced submaximal β-galactosidase activity. Naphthalene, 1,2,3,4,...
DiscoveryofaHighlySelectiveandH435R-SensitiveThyroidHormoneReceptorβAgonistQiuLi#BenqiangYao#ShitingZhaoZhouLuYanZhangQiupingXiangXishanWuHaonanYuChengZhangJunhuaLiXiaoxiZhuangDonghaiWuYongLi*andYongXu*CiteThis:J.Med.Chem.0657193−711ReadOnlineACCESSM
The Thyroid Hormone Receptor Beta Agonist Sobetirome Exerts Beneficial Effects in Pulmonary Fibrosis 来自 Semantic Scholar 喜欢 0 阅读量: 3 作者:T Baernthaler,F Ahangari,M Chioccioli,T Adams,K Rose,S Ding,N Kaminski DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4449 ...