METHODS OF TREATING LIVER DISORDERS OR LIPID DISORDERS WITH A THR-BETA AGONISTThe present invention provides a method for treating a liver disorder or lipid disorder in a subject in need thereof with 2-(3,5-dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-3,5-dioxo...
Resmetirom(MGL-3196) | Resmetirom (MGL-3196) is an orally active thyroid hormone receptor-beta (THR-beta) agonist with high specific uptake in liver. Selectivity for THR-beta may provide metabolic benefits of thyroid hormones in managing MASH. 链接 ...
中文名称:Beta-defensin 103 isoform X1, pig 单字母:H2N-MRIHYLLFALLFLFLMPLPGNGRIINTLQRYYCKIRRGRCAVLGCLPKEEQIGSCSVSGRKCC-OH 三字母:H2N -Met -Arg -Ile -His -Tyr -Leu -Leu -Phe -Ala -Leu -Leu -Phe -Leu -Phe -Leu -Met -Pro ...
编号:419400 CAS号: 单字母:H2N-GALFLGFLGAAGSTMGAWSQPKKKRKV-OH 立即咨询 纠错 基本属性产品描述文献链接合成路线相关产品 编号:419400 中文名称:细胞穿膜肽P-beta 英文名:P-beta 单字母:H2N-GALFLGFLGAAGSTMGAWSQPKKKRKV-OH 三字母:H2N -Gly
HETEROCYCLIC THR-BETA RECEPTOR AGONIST COMPOUND AND PREPARATION METHOD AND USE THEREFORA chemical compound shown in formula (I) below and an isomer thereof or a pharmaceutically acceptable salt thereof. The compound improves THR-β agonistic activity while also improving selectivity for THR-α, ...
Thus cardiac Thr164Ile subjects appear to be somewhat protected against agonist-induced desensitization.Bruck HLeineweber KUlrich ARadke JHeusch GPhilipp TBrodde OEAmerican Journal of PhysiologyBruck H, Leineweber K, Ulrich A, Radke J, Heusch G, Philipp T, et al. Thr164Ile polymorphism of the ...
The fat cells of Ile carriers displayed a 6 fold increase(P = 0.02) in the lipolytic EC_50 of terbutaline(a selectiveβ_2-adrenocptor agonist), but no change in the lipolytic action of dobutamine(a selectiveβ_1-adrenoceptor agonist), compared with the Thr carriers.Johan Hoffstetd...
Background The uncommon Thr164lle polymorphism of the beta(2)-adrenoceptor is associated with profoundly altered responses to agonist in vitro; however its effects on vascular responses in vivo are not known. Altered adrenergic vascular sensitivity may contribute to the decreased survival observed in ...