Thyroid Hormone Receptor-beta Agonist GC-1 Inhibits Met-beta-Catenin-Driven Hepatocellular Cancer. Am J Pathol. 2017;187(11):2473-85.Puliga E, Min Q, Tao J, Zhang R, Pradhan-Sundd T, Poddar M, et al. Thyroid hormone receptor-β agonist GC-1 inhibits Met-β- catenin-driven ...
(C) Crystallographic structure of the ligand binding domain of the human thyroid hormone (T3) receptor beta (rainbow colored, N-terminus in blue, C-terminus in red) complexed with triiodothyronine (T3).From Master A, Nauman A. THRB (Thyroid Hormone Receptor, Beta). Atlas Genet Cytogenet ...
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Mostyn A,Bos PM,Litten JC,et al.Differential effects of thyroid hormone manipulation andβadrenoceptor agonist administration on uncoupling protein mRNA abundance in adipose tissue and thermoregulation inneonatal pigs.Organogenesis. 2008Mostyn A,Bos PM,Litten JC,et al.Differential effects of thyroid ...
Since systemic side effects of T3 may preclude its clinical use, and hepatocytes mostly express T3 hormone receptor β (TRβ), we investigated if selective TRβ agonists like GC-1 may also have β-catenin-dependent hepatocyte mitogenic effects. Here we studied the effect of GC-1 and T3 in ...
Synthesis and preclinical testing of a selective beta-subtype agonist of thyroid hormone receptor ZTA-261 Article Open access 06 August 2024 References JF, C. Discovery of a new cure for goiter [De´- couverte d’un nouveau reme’de contre le goıˆtre]. Ann Chim Phys Paris 15, ...
The invention is directed toward a human glycoprotein hormone having at least one, two, three, four, or five basic amino acids in the α-subunit at positions selected from the group consisting of positions 11, 13, 14, 16, 17, and 20. The invention is also directed to a human glycoprotei...
Targeting thyroid hormone receptor-beta agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index. Proc Natl Acad Sci U S A. 2007;104(39):15490–5. Article CAS PubMed PubMed Central Google Scholar Ladenson PW, Kristensen JD, Ridgway EC, Olsson AG, ...
Dimerization of TRs results in dominant negative effects of mutant TRβs. Besides impairinggene transactivation, the mutant receptors also interfere with the function of wild-type receptor by dimerizing with it, resulting in resistance to thyroid hormone. On the other hand, individuals expressing a ...
One kind of antibodies (anti-TSH) have an allosteric conformation similar to TSH, and for this reason can stimulate the receptor by inducing high fT3 and fT4, and consequently increase both all the thyroid hormone concentrations and their actions, mainly acting on metabolism in the presence of ...