ConclusionActivation of PPAR-γ receptor can promote the transformation of M1-type THP-1 macrophages to M2 type, reduce the secretion of inflammatory factors, and reduce the lipid deposition of macrophages. KEYWORDS: Peroxisome proliferator-activated receptor-γ;Macrophage polarization;Lipid metabolism Corr...
12. ZHONG H, LIN H, PANG Q, et al. Macrophage ICAM-1 functions as a regulator of phagocytosis in LPS induced endotoxemia[J]. Inflamm Res, 2021,70(2):193-203. 13. 曾振国,钱克俭,刘芬.胞浆内线粒体DNA在脂多...
【Key words】 Macrophage Aged RBCs Phagocytosis Macrophage polarization 巨噬细胞是一类重要的免疫效应细胞,在炎 症的发生及恢复中发挥功能[1].巨噬细胞在应激不 同刺激的情况下,会分化成M1,M2或M2-like 3种 亚类[2-4]. 细菌分泌物或者某些细胞因子可诱导巨噬细胞 向M1亚类分化.脂多糖(lipopolysaccharide, ...
The expression of THP-1 macrophage surface CD86 was significantly increased after exposed to T. marneffei EVs. These findings support the hypothesis that fungal EVs play an important role in macrophage "classical" M1 polarization. T. marneffei EVs preparations also increased phagocy...
The present work, based on the combined analysis of the chemical and structural modifications of erionite fibres following incubation in human THP-1 macrophages and evaluation of cellular response, indicates that, upon macrophage phagocytosis, a large release of cations is counterbalanced by a ...
(PMA)and 1,25-dihydroxyvitamin D3(VD 3)are stimuli commonly used to induce macrophage differentiation in monocytic cell lines but the extent of differentiation in comparison to primary tissue macrophages is unclear.We have compared the phenotype of the promonocytic THP-1cell line after various ...
Monocytes and their macrophage and dendritic-cell progeny serve three main functions in the immune system. These are phagocytosis, antigen presentation, and cytokine production. THP-1 and U937 are (pro-) monocytic cell lines that can, also in vitro, be differentiated into either various types of...
比较不同诱导条件下的细胞THP-1细胞
THP-1 cell line: An in vitro cell model for immune modulation approach Highlights • THP-1 cell line is a suitable in vitro cell model to study modulation of monocyte and macrophage functions. • The use of THP-1 cell line can help supporting the eventual in vivo proven bioactivities of...
Comparison of transfection of THP-1 macrophage by three different methods YanWenjie1,SunWenkui1,2,LiPei1,2,SuXin1,2,ShiYi1,2(DepartmentofRespiratoryMedicine,1NanjingClinicalCollege,theSecondMilitaryMedicalUniversityofPLA,NanjingGeneralHospitalofNanjingMilitaryAreaCommandofPLA,Nanjing210002,China;2NanjingUniver...